Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

Although Merlin/NF2 was discovered two decades ago as a tumor suppressor underlying Neurofibromatosis type II, its precise molecular mechanism remains poorly understood. Recent studies in Drosophila revealed a potential link between Merlin and the Hippo pathway by placing Merlin genetically upstream...

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Veröffentlicht in:Cell 2013-09, Vol.154 (6), p.1342-1355
Hauptverfasser: Yin, Feng, Yu, Jianzhong, Zheng, Yonggang, Chen, Qian, Zhang, Nailing, Pan, Duojia
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Sprache:eng
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