A Novel Noncanonical Signaling Pathway for the µ-Opioid Receptor

The µ-opioid receptor (OPRM1) signals as a classic G protein–coupled receptor by activating heterotrimeric Gi/Go proteins resulting in adenylyl cyclase (AC) inhibition. Such AC inhibition is desensitized after prolonged agonist treatment. However, after receptor desensitization, the intracellular cA...

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Veröffentlicht in:	Molecular pharmacology 2013-12, Vol.84 (6), p.844-853
Hauptverfasser:	Zhang, Lei, Loh, Horace H., Law, Ping-Yee
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Enzyme Activation GRB2 Adaptor Protein - metabolism GTP-Binding Protein alpha Subunits, Gi-Go - metabolism HEK293 Cells Humans Phosphorylation Proto-Oncogene Proteins c-raf - metabolism ras Proteins - metabolism Receptors, Opioid, mu - metabolism Signal Transduction SOS1 Protein - metabolism src-Family Kinases - metabolism Tyrosine - metabolism
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