Saposin C Protects Glucocerebrosidase against α‑Synuclein Inhibition

Mutations in GBA1, the gene for glucocerebrosidase (GCase), are genetic risk factors for Parkinson disease (PD). α-Synuclein (α-Syn), a protein implicated in PD, interacts with GCase and efficiently inhibits enzyme activity. GCase deficiency causes the lysosomal storage disorder Gaucher disease (GD)...

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Veröffentlicht in:	Biochemistry (Easton) 2013-10, Vol.52 (41), p.7161-7163
Hauptverfasser:	Yap, Thai Leong, Gruschus, James M, Velayati, Arash, Sidransky, Ellen, Lee, Jennifer C
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - genetics alpha-Synuclein - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Glucosylceramidase - antagonists & inhibitors Glucosylceramidase - chemistry Glucosylceramidase - genetics Glucosylceramidase - metabolism Humans Kinetics Models, Molecular Mutation Parkinson Disease - enzymology Parkinson Disease - genetics Parkinson Disease - metabolism Protein Binding Saposins - chemistry Saposins - genetics Saposins - metabolism
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