SDF-1α in Glycan Nanoparticles Exhibits Full Activity and Reduces Pulmonary Hypertension in Rats

To establish a homing signal in the lung to recruit circulating stem cells for tissue repair, we formulated a nanoparticle, SDF-1α NP, by complexing SDF-1α with dextran sulfate and chitosan. The data show that SDF-1α was barely released from the nanoparticles over an extended period of time in vitro...

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Veröffentlicht in:	Biomacromolecules 2013-11, Vol.14 (11), p.4009-4020
Hauptverfasser:	Yin, Tao, Bader, Andrew R, Hou, Tim K, Maron, Bradley A, Kao, Derrick D, Qian, Ray, Kohane, Daniel S, Handy, Diane E, Loscalzo, Joseph, Zhang, Ying-Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols animal models Animals Antihypertensive agents Applied sciences Biological and medical sciences Cardiovascular system Chemokine CXCL12 - administration & dosage Chemokine CXCL12 - pharmacokinetics Chemokine CXCL12 - pharmacology Chemokine CXCL12 - therapeutic use chemotaxis chitosan Chitosan - chemistry dextran sulfate Dextran Sulfate - chemistry Exact sciences and technology Forms of application and semi-finished materials Humans hypertension Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - prevention & control Jurkat Cells lungs Male Medical sciences Miscellaneous Monocrotaline nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Pharmacology. Drug treatments Polymer industry, paints, wood Polysaccharides - administration & dosage Polysaccharides - chemistry Rats Rats, Sprague-Dawley stem cells Technology of polymers Time Factors tissue repair
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