DICER1 hotspot mutations in non-epithelial gonadal tumours

Background: Non-epithelial gonadal tumours largely comprise sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Specific somatic mutations in DICER1 , a microRNA maturation pathway gene, have been identified in these tumours. We conducted a study that aimed to confirm, refine and extend t...

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Veröffentlicht in:	British journal of cancer 2013-11, Vol.109 (10), p.2744-2750
Hauptverfasser:	Witkowski, L, Mattina, J, Schönberger, S, Murray, M J, Huntsman, D G, Reis-Filho, J S, McCluggage, W G, Nicholson, J C, Coleman, N, Calaminus, G, Schneider, D T, Arseneau, J, Stewart, C J R, Foulkes, W D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/68 631/208/737 631/67/1679 Adolescent Adult Aged Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Child Child, Preschool DEAD-box RNA Helicases - genetics DNA Mutational Analysis Drug Resistance Epidemiology Female Gene Frequency Genetics Genetics and Genomics Hematology Humans Infant Infant, Newborn Male Males Medical prognosis Medical research Medical sciences MicroRNAs Middle Aged Molecular Medicine Mutation Neoplasms, Germ Cell and Embryonal - epidemiology Neoplasms, Germ Cell and Embryonal - genetics Oncology Ovarian Neoplasms - epidemiology Ovarian Neoplasms - genetics Ovaries Pathology Pediatrics Ribonuclease III - genetics Sex Cord-Gonadal Stromal Tumors - epidemiology Sex Cord-Gonadal Stromal Tumors - genetics Testicular Neoplasms - epidemiology Testicular Neoplasms - genetics Tumors Young Adult
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