The fungus-growing termite Macrotermes natalensis harbors bacillaene-producing Bacillus sp. that inhibit potentially antagonistic fungi
The ancient fungus-growing termite (Mactrotermitinae) symbiosis involves the obligate association between a lineage of higher termites and basidiomycete Termitomyces cultivar fungi. Our investigation of the fungus-growing termite Macrotermes natalensis shows that Bacillus strains from M. natalensis...
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| Veröffentlicht in: | Scientific reports 2013-11, Vol.3 (1), p.3250-3250, Article 3250 |
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| creator | Um, Soohyun Fraimout, Antoine Sapountzis, Panagiotis Oh, Dong-Chan Poulsen, Michael |
| description | The ancient fungus-growing termite (Mactrotermitinae) symbiosis involves the obligate association between a lineage of higher termites and basidiomycete
Termitomyces
cultivar fungi. Our investigation of the fungus-growing termite
Macrotermes natalensis
shows that
Bacillus
strains from
M. natalensis
colonies produce a single major antibiotic, bacillaene A (1), which selectively inhibits known and putatively antagonistic fungi of
Termitomyces
. Comparative analyses of the genomes of symbiotic
Bacillus
strains revealed that they are phylogenetically closely related to
Bacillus subtilis
, their genomes have high homology with more than 90% of ORFs being 100% identical and the sequence identities across the biosynthetic gene cluster for bacillaene are higher between termite-associated strains than to the cluster previously reported in
B. subtilis
. Our findings suggest that this lineage of antibiotic-producing
Bacillus
may be a defensive symbiont involved in the protection of the fungus-growing termite cultivar. |
| doi_str_mv | 10.1038/srep03250 |
| format | Article |
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Termitomyces
cultivar fungi. Our investigation of the fungus-growing termite
Macrotermes natalensis
shows that
Bacillus
strains from
M. natalensis
colonies produce a single major antibiotic, bacillaene A (1), which selectively inhibits known and putatively antagonistic fungi of
Termitomyces
. Comparative analyses of the genomes of symbiotic
Bacillus
strains revealed that they are phylogenetically closely related to
Bacillus subtilis
, their genomes have high homology with more than 90% of ORFs being 100% identical and the sequence identities across the biosynthetic gene cluster for bacillaene are higher between termite-associated strains than to the cluster previously reported in
B. subtilis
. Our findings suggest that this lineage of antibiotic-producing
Bacillus
may be a defensive symbiont involved in the protection of the fungus-growing termite cultivar.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep03250</identifier><identifier>PMID: 24248063</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/23 ; 631/326/41/2530 ; 631/92/604 ; 82/16 ; 82/58 ; Animals ; Antibiotics ; Bacillus - chemistry ; Bacillus - classification ; Bacillus - genetics ; Biodiversity and Ecology ; Cultivars ; Environmental Sciences ; Fungi ; Genomes ; Homology ; Humanities and Social Sciences ; Isoptera - microbiology ; multidisciplinary ; Multigene Family ; Phylogeny ; Polyenes - chemistry ; Polyenes - isolation & purification ; Polyenes - pharmacology ; Science ; Sequence Analysis, DNA ; Symbiosis ; Termitomyces - drug effects</subject><ispartof>Scientific reports, 2013-11, Vol.3 (1), p.3250-3250, Article 3250</ispartof><rights>The Author(s) 2013</rights><rights>Copyright Nature Publishing Group Nov 2013</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2013, Macmillan Publishers Limited. All rights reserved 2013 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-6ca514928657dde91780279e00758133b16ba01e2342f026c20b6ff91ae737d53</citedby><cites>FETCH-LOGICAL-c512t-6ca514928657dde91780279e00758133b16ba01e2342f026c20b6ff91ae737d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832938/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832938/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24248063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03249825$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Um, Soohyun</creatorcontrib><creatorcontrib>Fraimout, Antoine</creatorcontrib><creatorcontrib>Sapountzis, Panagiotis</creatorcontrib><creatorcontrib>Oh, Dong-Chan</creatorcontrib><creatorcontrib>Poulsen, Michael</creatorcontrib><title>The fungus-growing termite Macrotermes natalensis harbors bacillaene-producing Bacillus sp. that inhibit potentially antagonistic fungi</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The ancient fungus-growing termite (Mactrotermitinae) symbiosis involves the obligate association between a lineage of higher termites and basidiomycete
Termitomyces
cultivar fungi. Our investigation of the fungus-growing termite
Macrotermes natalensis
shows that
Bacillus
strains from
M. natalensis
colonies produce a single major antibiotic, bacillaene A (1), which selectively inhibits known and putatively antagonistic fungi of
Termitomyces
. Comparative analyses of the genomes of symbiotic
Bacillus
strains revealed that they are phylogenetically closely related to
Bacillus subtilis
, their genomes have high homology with more than 90% of ORFs being 100% identical and the sequence identities across the biosynthetic gene cluster for bacillaene are higher between termite-associated strains than to the cluster previously reported in
B. subtilis
. Our findings suggest that this lineage of antibiotic-producing
Bacillus
may be a defensive symbiont involved in the protection of the fungus-growing termite cultivar.</description><subject>45/23</subject><subject>631/326/41/2530</subject><subject>631/92/604</subject><subject>82/16</subject><subject>82/58</subject><subject>Animals</subject><subject>Antibiotics</subject><subject>Bacillus - chemistry</subject><subject>Bacillus - classification</subject><subject>Bacillus - genetics</subject><subject>Biodiversity and Ecology</subject><subject>Cultivars</subject><subject>Environmental Sciences</subject><subject>Fungi</subject><subject>Genomes</subject><subject>Homology</subject><subject>Humanities and Social Sciences</subject><subject>Isoptera - microbiology</subject><subject>multidisciplinary</subject><subject>Multigene Family</subject><subject>Phylogeny</subject><subject>Polyenes - chemistry</subject><subject>Polyenes - isolation & purification</subject><subject>Polyenes - pharmacology</subject><subject>Science</subject><subject>Sequence Analysis, DNA</subject><subject>Symbiosis</subject><subject>Termitomyces - drug effects</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplUk1v1DAQtRCIVksP_AFkiQtUSvFnHF-QSlUo0iIu5Ww5jpO4ytrBdlr1F_C38XbLshQf_DHz5r3xzADwGqMzjGjzIUU7I0o4egaOCWK8IpSQ5wf3I3CS0g0qixPJsHwJjggjrEE1PQa_rkcL-8UPS6qGGO6cH2C2ceOyhd-0iWH7sAl6nfVkfXIJjjq2ISbYauOmSVtvqzmGbjHb2E8PxiXBNJ_BPOoMnR9d6zKcC5XPTk_TPdQ-6yF4l7IzD-ruFXjR6ynZk8dzBX58vry-uKrW3798vThfV4ZjkqvaaI6ZJE3NRddZiUWDiJAWIcEbTGmL61YjbAllpEekNgS1dd9LrK2gouN0BT7ueOel3djOlJSintQc3UbHexW0U_96vBvVEG4VbSiRZVuB9zuC8UnY1flabW2lF0w2hN_ign33KBbDz8WmrDYuGVuK5m1YksKMSyl4zVmBvn0CvQlL9KUUCjeFDglRi7_ipTGpNL7fZ4CR2k6D2k9Dwb45_Oke-af3BXC6A6Ti8oONB5L_sf0Gj6DAFQ</recordid><startdate>20131119</startdate><enddate>20131119</enddate><creator>Um, Soohyun</creator><creator>Fraimout, Antoine</creator><creator>Sapountzis, Panagiotis</creator><creator>Oh, Dong-Chan</creator><creator>Poulsen, Michael</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope></search><sort><creationdate>20131119</creationdate><title>The fungus-growing termite Macrotermes natalensis harbors bacillaene-producing Bacillus sp. that inhibit potentially antagonistic fungi</title><author>Um, Soohyun ; Fraimout, Antoine ; Sapountzis, Panagiotis ; Oh, Dong-Chan ; Poulsen, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-6ca514928657dde91780279e00758133b16ba01e2342f026c20b6ff91ae737d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>45/23</topic><topic>631/326/41/2530</topic><topic>631/92/604</topic><topic>82/16</topic><topic>82/58</topic><topic>Animals</topic><topic>Antibiotics</topic><topic>Bacillus - chemistry</topic><topic>Bacillus - classification</topic><topic>Bacillus - genetics</topic><topic>Biodiversity and Ecology</topic><topic>Cultivars</topic><topic>Environmental Sciences</topic><topic>Fungi</topic><topic>Genomes</topic><topic>Homology</topic><topic>Humanities and Social Sciences</topic><topic>Isoptera - microbiology</topic><topic>multidisciplinary</topic><topic>Multigene Family</topic><topic>Phylogeny</topic><topic>Polyenes - chemistry</topic><topic>Polyenes - isolation & purification</topic><topic>Polyenes - pharmacology</topic><topic>Science</topic><topic>Sequence Analysis, DNA</topic><topic>Symbiosis</topic><topic>Termitomyces - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Um, Soohyun</creatorcontrib><creatorcontrib>Fraimout, Antoine</creatorcontrib><creatorcontrib>Sapountzis, Panagiotis</creatorcontrib><creatorcontrib>Oh, Dong-Chan</creatorcontrib><creatorcontrib>Poulsen, Michael</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Um, Soohyun</au><au>Fraimout, Antoine</au><au>Sapountzis, Panagiotis</au><au>Oh, Dong-Chan</au><au>Poulsen, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The fungus-growing termite Macrotermes natalensis harbors bacillaene-producing Bacillus sp. that inhibit potentially antagonistic fungi</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2013-11-19</date><risdate>2013</risdate><volume>3</volume><issue>1</issue><spage>3250</spage><epage>3250</epage><pages>3250-3250</pages><artnum>3250</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The ancient fungus-growing termite (Mactrotermitinae) symbiosis involves the obligate association between a lineage of higher termites and basidiomycete
Termitomyces
cultivar fungi. Our investigation of the fungus-growing termite
Macrotermes natalensis
shows that
Bacillus
strains from
M. natalensis
colonies produce a single major antibiotic, bacillaene A (1), which selectively inhibits known and putatively antagonistic fungi of
Termitomyces
. Comparative analyses of the genomes of symbiotic
Bacillus
strains revealed that they are phylogenetically closely related to
Bacillus subtilis
, their genomes have high homology with more than 90% of ORFs being 100% identical and the sequence identities across the biosynthetic gene cluster for bacillaene are higher between termite-associated strains than to the cluster previously reported in
B. subtilis
. Our findings suggest that this lineage of antibiotic-producing
Bacillus
may be a defensive symbiont involved in the protection of the fungus-growing termite cultivar.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24248063</pmid><doi>10.1038/srep03250</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | SpringerOpen; Nature_OA刊; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | 45/23 631/326/41/2530 631/92/604 82/16 82/58 Animals Antibiotics Bacillus - chemistry Bacillus - classification Bacillus - genetics Biodiversity and Ecology Cultivars Environmental Sciences Fungi Genomes Homology Humanities and Social Sciences Isoptera - microbiology multidisciplinary Multigene Family Phylogeny Polyenes - chemistry Polyenes - isolation & purification Polyenes - pharmacology Science Sequence Analysis, DNA Symbiosis Termitomyces - drug effects |
| title | The fungus-growing termite Macrotermes natalensis harbors bacillaene-producing Bacillus sp. that inhibit potentially antagonistic fungi |
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