Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation

Tumor metastasis and lack of NKG2D ligand (NKG2DL) expression are associated with poor prognosis in patients with colon cancer. Here, we found that spironolactone (SPIR), an FDA-approved diuretic drug with a long-term safety profile, can up-regulate NKG2DL expression in multiple colon cancer cell li...

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Veröffentlicht in:	The Journal of experimental medicine 2013-11, Vol.210 (12), p.2675-2692
Hauptverfasser:	Leung, Wai-Hang, Vong, Queenie P, Lin, Wenwei, Janke, Laura, Chen, Taosheng, Leung, Wing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - secondary Cytotoxicity, Immunologic - drug effects GPI-Linked Proteins - genetics GPI-Linked Proteins - metabolism Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Ligands Mice Mice, Inbred C57BL Mice, Mutant Strains NK Cell Lectin-Like Receptor Subfamily K - metabolism Receptors, Mineralocorticoid - metabolism Retinoid X Receptor gamma - agonists Retinoid X Receptor gamma - antagonists & inhibitors Retinoid X Receptor gamma - genetics RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Signal Transduction Spironolactone - pharmacology Tissue Inhibitor of Metalloproteinase-2 - genetics Tissue Inhibitor of Metalloproteinase-3 - genetics Up-Regulation - drug effects Xenograft Model Antitumor Assays
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