IL-2 coordinates IL-2-producing and regulatory T cell interplay

Many species of bacteria use quorum sensing to sense the amount of secreted metabolites and to adapt their growth according to their population density. We asked whether similar mechanisms would operate in lymphocyte homeostasis. We investigated the regulation of the size of interleukin-2 (IL-2)-pro...

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Veröffentlicht in:	The Journal of experimental medicine 2013-11, Vol.210 (12), p.2707-2720
Hauptverfasser:	Amado, Inês F, Berges, Julien, Luther, Rita J, Mailhé, Marie-Pierre, Garcia, Sylvie, Bandeira, Antonio, Weaver, Casey, Liston, Adrian, Freitas, Antonio A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - classification CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Feedback, Physiological Female Genes, Reporter Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Immunology Interleukin-2 - biosynthesis Interleukin-2 - deficiency Interleukin-2 - genetics Life Sciences Lymphocyte Activation Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Self Tolerance Signal Transduction T-Lymphocytes, Regulatory - classification T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism
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