The cohesin complex regulates immunoglobulin class switch recombination

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the transcription-coupled recruitment of activation-induced cytidine deaminase (AID) to switch regions and by the subsequent generation of double-stranded DNA breaks (DSBs). These DNA breaks are ultimately resolved through the nonh...

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Veröffentlicht in:	The Journal of experimental medicine 2013-11, Vol.210 (12), p.2495-2502
Hauptverfasser:	Thomas-Claudepierre, Anne-Sophie, Schiavo, Ebe, Heyer, Vincent, Fournier, Marjorie, Page, Adeline, Robert, Isabelle, Reina-San-Martin, Bernardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brief Definitive Report Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line Chondroitin Sulfate Proteoglycans - metabolism Chromosomal Proteins, Non-Histone - antagonists & inhibitors Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Cohesins Cytidine Deaminase - metabolism DNA End-Joining Repair Gene Knockdown Techniques Immunoglobulin Class Switching Mice Recombination, Genetic
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