Gamma-irradiated liposome/noisome and lipogelosome/niogelosome formulations for the treatment of rheumatoid arthritis

Gamma-irradiated liposome/noisome and lipogelosome/niogelosome formulations for the treatment of rheumatoid arthritis

Treatment of rheumatoid arthritis by intraarticular administration of anti-inflammatory drugs encapsulated in drug delivery systems, such as liposomes/niosomes and lipogelosomes/niogelosomes, prolongs the residence time of the drugs in the joint. It was therefore anticipated that liposome/niosome en...

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Veröffentlicht in:Interventional medicine and applied science 2013-06, Vol.5 (2), p.60-69
Hauptverfasser: Turker, Selcan, Ozer, A Yekta, Kiliç, Ekrem, Ozalp, Meral, Colak, Seyda, Korkmaz, Mustafa
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Hematology, Cancer and Oncology, Gastroenterology and Hepatology, Nephrology and Urology, Pediatrics, Surgery, Medical Research, Clinical Medicine and Cardiovascular and Respiratory Systems
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container_issue 2
container_start_page 60
container_title Interventional medicine and applied science
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creator Turker, Selcan
Ozer, A Yekta
Kiliç, Ekrem
Ozalp, Meral
Colak, Seyda
Korkmaz, Mustafa
description Treatment of rheumatoid arthritis by intraarticular administration of anti-inflammatory drugs encapsulated in drug delivery systems, such as liposomes/niosomes and lipogelosomes/niogelosomes, prolongs the residence time of the drugs in the joint. It was therefore anticipated that liposome/niosome entrapment would enhance the efficacy of drugs in the inflammatory sides. Liposomes are good candidates for the local delivery of therapeutic agents, such as diclofenac sodium (DFNa), for intraarticular delivery. Drugs for parenteral delivery must be sterile, and radiation sterilization is a method recognized by pharmacopoeias to achieve sterility of drugs. However, irradiation might also affect the performance of drug delivery systems. One of the most critical points is irradiation dose, because certain undesirable chemical and physical changes may accompany with the treatment, especially with the traditionally applied dose of 25 kGy. The present study aims to determine the effects of gamma irradiation on DFNa-loaded liposomes/niosomes and lipogelosomes/niogelosomes for the treatment of rheumatoid arthritis.
doi_str_mv 10.1556/IMAS.5.2013.2.2
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subjects Hematology, Cancer and Oncology, Gastroenterology and Hepatology, Nephrology and Urology, Pediatrics, Surgery, Medical Research, Clinical Medicine and Cardiovascular and Respiratory Systems
Original Paper
title Gamma-irradiated liposome/noisome and lipogelosome/niogelosome formulations for the treatment of rheumatoid arthritis
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