Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors
The reduced folate carrier (RFC, SLC19A1), thiamine transporter-1 (ThTr1, SLC19A2) and thiamine transporter-2 (ThTr2, SLC19A3) evolved from the same family of solute carriers. SLC19A1 transports folates but not thiamine. SLC19A2 and SLC19A3 transport thiamine but not folates. SLC19A1 and SLC19A2 del...
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| Veröffentlicht in: | Molecular aspects of medicine 2013-04, Vol.34 (2-3), p.373-385 |
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| creator | Zhao, Rongbao Goldman, I. David |
| description | The reduced folate carrier (RFC, SLC19A1), thiamine transporter-1 (ThTr1, SLC19A2) and thiamine transporter-2 (ThTr2, SLC19A3) evolved from the same family of solute carriers. SLC19A1 transports folates but not thiamine. SLC19A2 and SLC19A3 transport thiamine but not folates. SLC19A1 and SLC19A2 deliver their substrates to systemic tissues; SLC19A3 mediates intestinal thiamine absorption. The proton-coupled folate transporter (PCFT, SLC46A1) is the mechanism by which folates are absorbed across the apical-brush-border membrane of the proximal small intestine. Two folate receptors (FOLR1 and FOLR2) mediate folate transport across epithelia by an endocytic process. Folate transporters are routes of delivery of drugs for the treatment of cancer and inflammatory diseases. There are autosomal recessive disorders associated with mutations in genes encoded for SLC46A1 (hereditary folate malabsorption), FOLR1 (cerebral folate deficiency), SLC19A2 (thiamine-responsive megaloblastic anemia), and SLC19A3 (biotin-responsive basal ganglia disease). |
| doi_str_mv | 10.1016/j.mam.2012.07.006 |
| format | Article |
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David</creator><creatorcontrib>Zhao, Rongbao ; Goldman, I. David</creatorcontrib><description>The reduced folate carrier (RFC, SLC19A1), thiamine transporter-1 (ThTr1, SLC19A2) and thiamine transporter-2 (ThTr2, SLC19A3) evolved from the same family of solute carriers. SLC19A1 transports folates but not thiamine. SLC19A2 and SLC19A3 transport thiamine but not folates. SLC19A1 and SLC19A2 deliver their substrates to systemic tissues; SLC19A3 mediates intestinal thiamine absorption. The proton-coupled folate transporter (PCFT, SLC46A1) is the mechanism by which folates are absorbed across the apical-brush-border membrane of the proximal small intestine. Two folate receptors (FOLR1 and FOLR2) mediate folate transport across epithelia by an endocytic process. Folate transporters are routes of delivery of drugs for the treatment of cancer and inflammatory diseases. There are autosomal recessive disorders associated with mutations in genes encoded for SLC46A1 (hereditary folate malabsorption), FOLR1 (cerebral folate deficiency), SLC19A2 (thiamine-responsive megaloblastic anemia), and SLC19A3 (biotin-responsive basal ganglia disease).</description><identifier>ISSN: 0098-2997</identifier><identifier>EISSN: 1872-9452</identifier><identifier>DOI: 10.1016/j.mam.2012.07.006</identifier><identifier>PMID: 23506878</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Endocytosis - physiology ; Epithelium - metabolism ; Folate ; Folate receptor ; Folic Acid - metabolism ; Folic Acid Transporters - genetics ; Folic Acid Transporters - metabolism ; Folic Acid Transporters - physiology ; Hereditary folate malabsorption ; Humans ; Intestine, Small - metabolism ; Membrane Transport Proteins - metabolism ; Microvilli - metabolism ; Models, Biological ; Molecular Structure ; Multigene Family - genetics ; Mutation - genetics ; Proton-Coupled Folate Transporter - metabolism ; Reduced Folate Carrier Protein - metabolism ; SCL19A1 ; SCL46A1 ; SLC19A2 ; SLC19A3 ; Thiamine ; Thiamine - metabolism ; Thiamine-responsive megaloblastic anemia</subject><ispartof>Molecular aspects of medicine, 2013-04, Vol.34 (2-3), p.373-385</ispartof><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><rights>2012 Elsevier Ltd. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-4ed4101532a95b995753759e0366c812f47ccc490fa580b15ca13a6675cc97a93</citedby><cites>FETCH-LOGICAL-c517t-4ed4101532a95b995753759e0366c812f47ccc490fa580b15ca13a6675cc97a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mam.2012.07.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23506878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Rongbao</creatorcontrib><creatorcontrib>Goldman, I. David</creatorcontrib><title>Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors</title><title>Molecular aspects of medicine</title><addtitle>Mol Aspects Med</addtitle><description>The reduced folate carrier (RFC, SLC19A1), thiamine transporter-1 (ThTr1, SLC19A2) and thiamine transporter-2 (ThTr2, SLC19A3) evolved from the same family of solute carriers. SLC19A1 transports folates but not thiamine. SLC19A2 and SLC19A3 transport thiamine but not folates. SLC19A1 and SLC19A2 deliver their substrates to systemic tissues; SLC19A3 mediates intestinal thiamine absorption. The proton-coupled folate transporter (PCFT, SLC46A1) is the mechanism by which folates are absorbed across the apical-brush-border membrane of the proximal small intestine. Two folate receptors (FOLR1 and FOLR2) mediate folate transport across epithelia by an endocytic process. Folate transporters are routes of delivery of drugs for the treatment of cancer and inflammatory diseases. There are autosomal recessive disorders associated with mutations in genes encoded for SLC46A1 (hereditary folate malabsorption), FOLR1 (cerebral folate deficiency), SLC19A2 (thiamine-responsive megaloblastic anemia), and SLC19A3 (biotin-responsive basal ganglia disease).</description><subject>Endocytosis - physiology</subject><subject>Epithelium - metabolism</subject><subject>Folate</subject><subject>Folate receptor</subject><subject>Folic Acid - metabolism</subject><subject>Folic Acid Transporters - genetics</subject><subject>Folic Acid Transporters - metabolism</subject><subject>Folic Acid Transporters - physiology</subject><subject>Hereditary folate malabsorption</subject><subject>Humans</subject><subject>Intestine, Small - metabolism</subject><subject>Membrane Transport Proteins - metabolism</subject><subject>Microvilli - metabolism</subject><subject>Models, Biological</subject><subject>Molecular Structure</subject><subject>Multigene Family - genetics</subject><subject>Mutation - genetics</subject><subject>Proton-Coupled Folate Transporter - metabolism</subject><subject>Reduced Folate Carrier Protein - metabolism</subject><subject>SCL19A1</subject><subject>SCL46A1</subject><subject>SLC19A2</subject><subject>SLC19A3</subject><subject>Thiamine</subject><subject>Thiamine - metabolism</subject><subject>Thiamine-responsive megaloblastic anemia</subject><issn>0098-2997</issn><issn>1872-9452</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uEzEUhS0EakPpA7BBsyyLGXzH4z8hIUURLUiRWLSsrRuPhzqaGQfbidS3x2lKVTasrCufe-xzPkLeA22Agvi0bSacmpZC21DZUCpekQUo2da64-1rsqBUq7rVWp6TtyltKQUuBT8j5y3jVCipFiRchxGzq3Duq3zvcfKzq3LEOe1CzC6manK9L4q-2jxUA1o_-ozZH1xlMUZ_VFzdrlegl1CzR5sydWIJHx-H4WQfnXW7HGJ6R94MOCZ3-XRekJ_XX-9W3-r1j5vvq-W6thxkrjvXdyUiZy1qvtGaS84k144yIayCduiktbbTdECu6Aa4RWAohOTWaomaXZAvJ9_dflMSWDeXUKPZRT9hfDABvfn3Zvb35lc4GKYYcFDF4OrJIIbfe5eymXyybhxxdmGfDDBQVPNOiSKFk9TGkFJ0w_MzQM0RlNmaAsocQRkqTQFVdj68_N_zxl8yRfD5JHClpUPp2STr3WwLjVJmNn3w_7H_Awq4ow0</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Zhao, Rongbao</creator><creator>Goldman, I. David</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130401</creationdate><title>Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors</title><author>Zhao, Rongbao ; Goldman, I. David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-4ed4101532a95b995753759e0366c812f47ccc490fa580b15ca13a6675cc97a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Endocytosis - physiology</topic><topic>Epithelium - metabolism</topic><topic>Folate</topic><topic>Folate receptor</topic><topic>Folic Acid - metabolism</topic><topic>Folic Acid Transporters - genetics</topic><topic>Folic Acid Transporters - metabolism</topic><topic>Folic Acid Transporters - physiology</topic><topic>Hereditary folate malabsorption</topic><topic>Humans</topic><topic>Intestine, Small - metabolism</topic><topic>Membrane Transport Proteins - metabolism</topic><topic>Microvilli - metabolism</topic><topic>Models, Biological</topic><topic>Molecular Structure</topic><topic>Multigene Family - genetics</topic><topic>Mutation - genetics</topic><topic>Proton-Coupled Folate Transporter - metabolism</topic><topic>Reduced Folate Carrier Protein - metabolism</topic><topic>SCL19A1</topic><topic>SCL46A1</topic><topic>SLC19A2</topic><topic>SLC19A3</topic><topic>Thiamine</topic><topic>Thiamine - metabolism</topic><topic>Thiamine-responsive megaloblastic anemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Rongbao</creatorcontrib><creatorcontrib>Goldman, I. David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular aspects of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Rongbao</au><au>Goldman, I. David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors</atitle><jtitle>Molecular aspects of medicine</jtitle><addtitle>Mol Aspects Med</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>34</volume><issue>2-3</issue><spage>373</spage><epage>385</epage><pages>373-385</pages><issn>0098-2997</issn><eissn>1872-9452</eissn><abstract>The reduced folate carrier (RFC, SLC19A1), thiamine transporter-1 (ThTr1, SLC19A2) and thiamine transporter-2 (ThTr2, SLC19A3) evolved from the same family of solute carriers. SLC19A1 transports folates but not thiamine. SLC19A2 and SLC19A3 transport thiamine but not folates. SLC19A1 and SLC19A2 deliver their substrates to systemic tissues; SLC19A3 mediates intestinal thiamine absorption. The proton-coupled folate transporter (PCFT, SLC46A1) is the mechanism by which folates are absorbed across the apical-brush-border membrane of the proximal small intestine. Two folate receptors (FOLR1 and FOLR2) mediate folate transport across epithelia by an endocytic process. Folate transporters are routes of delivery of drugs for the treatment of cancer and inflammatory diseases. There are autosomal recessive disorders associated with mutations in genes encoded for SLC46A1 (hereditary folate malabsorption), FOLR1 (cerebral folate deficiency), SLC19A2 (thiamine-responsive megaloblastic anemia), and SLC19A3 (biotin-responsive basal ganglia disease).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23506878</pmid><doi>10.1016/j.mam.2012.07.006</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Endocytosis - physiology Epithelium - metabolism Folate Folate receptor Folic Acid - metabolism Folic Acid Transporters - genetics Folic Acid Transporters - metabolism Folic Acid Transporters - physiology Hereditary folate malabsorption Humans Intestine, Small - metabolism Membrane Transport Proteins - metabolism Microvilli - metabolism Models, Biological Molecular Structure Multigene Family - genetics Mutation - genetics Proton-Coupled Folate Transporter - metabolism Reduced Folate Carrier Protein - metabolism SCL19A1 SCL46A1 SLC19A2 SLC19A3 Thiamine Thiamine - metabolism Thiamine-responsive megaloblastic anemia |
| title | Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors |
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