Fetal polymorphisms at the ABCB1-transporter gene locus are associated with susceptibility to non-syndromic oral cleft malformations

ATP-binding cassette (ABC) proteins in the placenta regulate fetal exposure to xenobiotics. We hypothesized that functional polymorphisms in ABC genes influence risk for non-syndromic oral clefts (NSOC). Both family-based and case-control studies were undertaken to evaluate the association of nine p...

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Veröffentlicht in:	European journal of human genetics : EJHG 2013-12, Vol.21 (12), p.1436-1441
Hauptverfasser:	Omoumi, Ardeshir, Wang, Zihua, Yeow, Vincent, Wu-Chou, Yah-Huei, Chen, Philip K, Ruczinski, Ingo, Cheng, Joanne, Cheah, Felicia S H, Lee, Caroline G, Beaty, Terri H, Chong, Samuel S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Cancer Case-Control Studies Cleft Lip - genetics Cleft Palate - genetics Cord blood Fetus - abnormalities Fetuses Genetic Predisposition to Disease - genetics Genetics Genomics Genotype Hospitals Humans Infant, Newborn Maternal effects Medical research Medicine Neonates Pediatrics Peripheral blood Placenta Polymorphism Polymorphism, Single Nucleotide - genetics Protein expression Proteins Singapore Single-nucleotide polymorphism Studies Taiwan Xenobiotics
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