Association between −308 G/A TNF-α Polymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome
Background and Aim. Normal weight obese (NWO) syndrome is characterized by normal body mass index (BMI), but high amount of fat mass and reduced lean mass. We evaluated allelic frequency of the G/A −308 TNF-α polymorphism and prevalence of sarcopenia in NWO. Methods. We enrolled 120 Italian healthy...
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| Veröffentlicht in: | Disease markers 2013-01, Vol.2013 (2013), p.1-9 |
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| creator | De Lorenzo, Antonino Monteleone, G. Iacopino, L. Petramala, Luigi Sarlo, Francesca Di Renzo, Laura Colica, Carmen |
| description | Background and Aim. Normal weight obese (NWO) syndrome is characterized by normal body mass index (BMI), but high amount of fat mass and reduced lean mass. We evaluated allelic frequency of the G/A −308 TNF-α polymorphism and prevalence of sarcopenia in NWO. Methods. We enrolled 120 Italian healthy women, distinguished into 3 groups: normal weight (NW); NWO, and preobese-obese (PreOB/OB) and evaluated anthropometric parameters, body composition by dual X-ray absorptiometry, blood tests, and genotyping of G/A −308 TNF-α polymorphism. Results. We found a positive association between sarcopenic obesity and −308 TNF-α polymorphism. All obese women were sarcopenic and were no carrier of mutation (G/G). Among all G/G, NWO showed significant differences in lean mass and total body lean mass (TBLean) with respect to NW and PreOB/OB (P |
| doi_str_mv | 10.1155/2013/983424 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3830785</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1462764899</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-90ca52258eca9d264d5c03f842c64b55d2f5d5744f31e3455c2417f7380d37bd3</originalsourceid><addsrcrecordid>eNqNkc1u1DAQxyMEotvCiTvyEYHC-nNjX5BWFS2V-oG0RRwtx550TRM7tRPafQPOnHgNXoSH4ElItaUqN06j0fzmNyP9i-IFwW8JEWJOMWFzJRmn_FExI7ISpVww_LiYYVrJElOOd4rdnL9gTKji6mmxQzmVQhE2K34sc47Wm8HHgGoYrgEC-v3tO8MSHc6X6Pz0oPz1E32M7aaLqV_73CETHFr2PQTn7diahFaX0MJgWnQyZtsCOjE5o6Pg4AaZjMzUp0tIKDZoZZKN06Y3yAd0GlM3bX0Gf7Ee0FkNGdBqE1yKHTwrnjSmzfD8ru4Vnw7en-9_KI_PDo_2l8el5UwNpcLWCEqFBGuUowvuhMWskZzaBa-FcLQRTlScN4wA40JYyknVVExix6rasb3i3dbbj3UHzkIYkml1n3xn0kZH4_W_k-DX-iJ-1UwyXEkxCV7dCVK8GiEPuvPZQtuaAHHMmvAFrRZcKjWhb7aoTTHnBM39GYL1bZb6Nku9zXKiXz787J79G94EvN4Cax-cufb_Z4MJgcY8gBmhTLE_BNuykA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1462764899</pqid></control><display><type>article</type><title>Association between −308 G/A TNF-α Polymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>De Lorenzo, Antonino ; Monteleone, G. ; Iacopino, L. ; Petramala, Luigi ; Sarlo, Francesca ; Di Renzo, Laura ; Colica, Carmen</creator><contributor>Perry, George</contributor><creatorcontrib>De Lorenzo, Antonino ; Monteleone, G. ; Iacopino, L. ; Petramala, Luigi ; Sarlo, Francesca ; Di Renzo, Laura ; Colica, Carmen ; Perry, George</creatorcontrib><description>Background and Aim. Normal weight obese (NWO) syndrome is characterized by normal body mass index (BMI), but high amount of fat mass and reduced lean mass. We evaluated allelic frequency of the G/A −308 TNF-α polymorphism and prevalence of sarcopenia in NWO. Methods. We enrolled 120 Italian healthy women, distinguished into 3 groups: normal weight (NW); NWO, and preobese-obese (PreOB/OB) and evaluated anthropometric parameters, body composition by dual X-ray absorptiometry, blood tests, and genotyping of G/A −308 TNF-α polymorphism. Results. We found a positive association between sarcopenic obesity and −308 TNF-α polymorphism. All obese women were sarcopenic and were no carrier of mutation (G/G). Among all G/G, NWO showed significant differences in lean mass and total body lean mass (TBLean) with respect to NW and PreOB/OB (P<0.001). Regarding appendicular skeletal muscle mass index values, 4.21% of NW were sarcopenic (50% G/G and 50% G/A); the same percentage was observed in NWO subjects (100% G/G). Moreover, 2.10% of PreOB/OB were sarcopenic and all were G/G. Conclusion. Our study suggests that TNF-α polymorphism contributes to sarcopenic obesity susceptibility, in association with body composition. This is the first study that shows the importance of TNF-α polymorphism to determine TBLean variation in NWO syndrome.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2013/983424</identifier><identifier>PMID: 24285913</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adiposity - genetics ; Adult ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Middle Aged ; Muscle, Skeletal - pathology ; Obesity - genetics ; Polymorphism, Single Nucleotide ; Sarcopenia - genetics ; Tumor Necrosis Factor-alpha - genetics ; Young Adult</subject><ispartof>Disease markers, 2013-01, Vol.2013 (2013), p.1-9</ispartof><rights>Copyright © 2013 L. Di Renzo et al.</rights><rights>Copyright © 2013 L. Di Renzo et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-90ca52258eca9d264d5c03f842c64b55d2f5d5744f31e3455c2417f7380d37bd3</citedby><cites>FETCH-LOGICAL-c439t-90ca52258eca9d264d5c03f842c64b55d2f5d5744f31e3455c2417f7380d37bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830785/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830785/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24285913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Perry, George</contributor><creatorcontrib>De Lorenzo, Antonino</creatorcontrib><creatorcontrib>Monteleone, G.</creatorcontrib><creatorcontrib>Iacopino, L.</creatorcontrib><creatorcontrib>Petramala, Luigi</creatorcontrib><creatorcontrib>Sarlo, Francesca</creatorcontrib><creatorcontrib>Di Renzo, Laura</creatorcontrib><creatorcontrib>Colica, Carmen</creatorcontrib><title>Association between −308 G/A TNF-α Polymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Background and Aim. Normal weight obese (NWO) syndrome is characterized by normal body mass index (BMI), but high amount of fat mass and reduced lean mass. We evaluated allelic frequency of the G/A −308 TNF-α polymorphism and prevalence of sarcopenia in NWO. Methods. We enrolled 120 Italian healthy women, distinguished into 3 groups: normal weight (NW); NWO, and preobese-obese (PreOB/OB) and evaluated anthropometric parameters, body composition by dual X-ray absorptiometry, blood tests, and genotyping of G/A −308 TNF-α polymorphism. Results. We found a positive association between sarcopenic obesity and −308 TNF-α polymorphism. All obese women were sarcopenic and were no carrier of mutation (G/G). Among all G/G, NWO showed significant differences in lean mass and total body lean mass (TBLean) with respect to NW and PreOB/OB (P<0.001). Regarding appendicular skeletal muscle mass index values, 4.21% of NW were sarcopenic (50% G/G and 50% G/A); the same percentage was observed in NWO subjects (100% G/G). Moreover, 2.10% of PreOB/OB were sarcopenic and all were G/G. Conclusion. Our study suggests that TNF-α polymorphism contributes to sarcopenic obesity susceptibility, in association with body composition. This is the first study that shows the importance of TNF-α polymorphism to determine TBLean variation in NWO syndrome.</description><subject>Adiposity - genetics</subject><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - pathology</subject><subject>Obesity - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Sarcopenia - genetics</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Young Adult</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAQxyMEotvCiTvyEYHC-nNjX5BWFS2V-oG0RRwtx550TRM7tRPafQPOnHgNXoSH4ElItaUqN06j0fzmNyP9i-IFwW8JEWJOMWFzJRmn_FExI7ISpVww_LiYYVrJElOOd4rdnL9gTKji6mmxQzmVQhE2K34sc47Wm8HHgGoYrgEC-v3tO8MSHc6X6Pz0oPz1E32M7aaLqV_73CETHFr2PQTn7diahFaX0MJgWnQyZtsCOjE5o6Pg4AaZjMzUp0tIKDZoZZKN06Y3yAd0GlM3bX0Gf7Ee0FkNGdBqE1yKHTwrnjSmzfD8ru4Vnw7en-9_KI_PDo_2l8el5UwNpcLWCEqFBGuUowvuhMWskZzaBa-FcLQRTlScN4wA40JYyknVVExix6rasb3i3dbbj3UHzkIYkml1n3xn0kZH4_W_k-DX-iJ-1UwyXEkxCV7dCVK8GiEPuvPZQtuaAHHMmvAFrRZcKjWhb7aoTTHnBM39GYL1bZb6Nku9zXKiXz787J79G94EvN4Cax-cufb_Z4MJgcY8gBmhTLE_BNuykA</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>De Lorenzo, Antonino</creator><creator>Monteleone, G.</creator><creator>Iacopino, L.</creator><creator>Petramala, Luigi</creator><creator>Sarlo, Francesca</creator><creator>Di Renzo, Laura</creator><creator>Colica, Carmen</creator><general>Hindawi Publishing Corporation</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Association between −308 G/A TNF-α Polymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome</title><author>De Lorenzo, Antonino ; Monteleone, G. ; Iacopino, L. ; Petramala, Luigi ; Sarlo, Francesca ; Di Renzo, Laura ; Colica, Carmen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-90ca52258eca9d264d5c03f842c64b55d2f5d5744f31e3455c2417f7380d37bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adiposity - genetics</topic><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - pathology</topic><topic>Obesity - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Sarcopenia - genetics</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Lorenzo, Antonino</creatorcontrib><creatorcontrib>Monteleone, G.</creatorcontrib><creatorcontrib>Iacopino, L.</creatorcontrib><creatorcontrib>Petramala, Luigi</creatorcontrib><creatorcontrib>Sarlo, Francesca</creatorcontrib><creatorcontrib>Di Renzo, Laura</creatorcontrib><creatorcontrib>Colica, Carmen</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Lorenzo, Antonino</au><au>Monteleone, G.</au><au>Iacopino, L.</au><au>Petramala, Luigi</au><au>Sarlo, Francesca</au><au>Di Renzo, Laura</au><au>Colica, Carmen</au><au>Perry, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between −308 G/A TNF-α Polymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Background and Aim. Normal weight obese (NWO) syndrome is characterized by normal body mass index (BMI), but high amount of fat mass and reduced lean mass. We evaluated allelic frequency of the G/A −308 TNF-α polymorphism and prevalence of sarcopenia in NWO. Methods. We enrolled 120 Italian healthy women, distinguished into 3 groups: normal weight (NW); NWO, and preobese-obese (PreOB/OB) and evaluated anthropometric parameters, body composition by dual X-ray absorptiometry, blood tests, and genotyping of G/A −308 TNF-α polymorphism. Results. We found a positive association between sarcopenic obesity and −308 TNF-α polymorphism. All obese women were sarcopenic and were no carrier of mutation (G/G). Among all G/G, NWO showed significant differences in lean mass and total body lean mass (TBLean) with respect to NW and PreOB/OB (P<0.001). Regarding appendicular skeletal muscle mass index values, 4.21% of NW were sarcopenic (50% G/G and 50% G/A); the same percentage was observed in NWO subjects (100% G/G). Moreover, 2.10% of PreOB/OB were sarcopenic and all were G/G. Conclusion. Our study suggests that TNF-α polymorphism contributes to sarcopenic obesity susceptibility, in association with body composition. This is the first study that shows the importance of TNF-α polymorphism to determine TBLean variation in NWO syndrome.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>24285913</pmid><doi>10.1155/2013/983424</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Adiposity - genetics Adult Case-Control Studies Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Middle Aged Muscle, Skeletal - pathology Obesity - genetics Polymorphism, Single Nucleotide Sarcopenia - genetics Tumor Necrosis Factor-alpha - genetics Young Adult |
| title | Association between −308 G/A TNF-α Polymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome |
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