Methods to promote Notch signaling at the biomaterial interface and evaluation in a rafted organ culture model

The Notch signaling pathway is a promising target for controlling cell fate choices at the biomaterial‐tissue interface. Building on our previous work in developing Notch‐signaling biomaterials, we evaluated various immobilization schemes for Notch ligands, and their effect on human foreskin keratin...

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2009-11, Vol.91A (2), p.436-446
Hauptverfasser:	Beckstead, Benjamin L., Tung, Jason C., Liang, Katharine J., Tavakkol, Zarry, Usui, Marcia L., Olerud, John E., Giachelli, Cecilia M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biocompatible Materials - chemistry Biocompatible Materials - metabolism biomaterials Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - metabolism Cell Differentiation Cells, Cultured Humans Immobilized Proteins - chemistry Immobilized Proteins - metabolism Implants, Experimental Intercellular Signaling Peptides and Proteins - chemistry Intercellular Signaling Peptides and Proteins - metabolism Jagged-1 Jagged-1 Protein Keratinocytes - cytology Keratinocytes - metabolism Membrane Proteins - chemistry Membrane Proteins - metabolism Methacrylates - chemistry Molecular Sequence Data Notch organ culture Organ Culture Techniques - methods Receptors, Notch - metabolism Serrate-Jagged Proteins Signal Transduction Skin - cytology stem cells
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