Blockade of the Serotonin 5-HT2A Receptor Suppresses Cue-Evoked Reinstatement of Cocaine-Seeking Behavior in a Rat Self-Administration Model

The serotonin 5-HT 2A receptor (5-HT 2A R) may play a role in reinstatement of drug-seeking. This study investigated the ability of a selective 5-HT 2A R antagonist to suppress reinstatement evoked by exposure to cues conditioned to cocaine self-administration. Cocaine self-administration (0.75 mg/k...

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Veröffentlicht in:	Behavioral neuroscience 2009-04, Vol.123 (2), p.382-396
Hauptverfasser:	Nic Dhonnchadha, B. Á, Fox, R. G, Stutz, S. J, Rice, K. C, Cunningham, K. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animal Animal Models Animals Behavioral psychophysiology Biological and medical sciences Cocaine Cocaine - administration & dosage Cocaine-Related Disorders - psychology Conditioning, Operant - drug effects Cues Disease Models, Animal Dopamine Uptake Inhibitors - administration & dosage Dose-Response Relationship, Drug Drug Seeking Drug Self Administration Extinction, Psychological - drug effects Fluorobenzenes - pharmacology Food Deprivation - physiology Fundamental and applied biological sciences. Psychology Male Piperidines - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Reinstatement Self Administration Serotonin Serotonin 5-HT2 Receptor Antagonists Serotonin Antagonists - pharmacology
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