Development of small-molecule inhibitors targeting adipose triglyceride lipase

A competitive inhibitor of the lipase ATGL reduces the availability of adipocyte fatty acids, causing insulin resistance in insulin-sensitive tissues. Adipose triglyceride lipase (ATGL) is rate limiting in the mobilization of fatty acids from cellular triglyceride stores. This central role in lipoly...

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Veröffentlicht in:	Nature chemical biology 2013-12, Vol.9 (12), p.785-787
Hauptverfasser:	Mayer, Nicole, Schweiger, Martina, Romauch, Matthias, Grabner, Gernot F, Eichmann, Thomas O, Fuchs, Elisabeth, Ivkovic, Jakov, Heier, Christoph, Mrak, Irina, Lass, Achim, Höfler, Gerald, Fledelius, Christian, Zechner, Rudolf, Zimmermann, Robert, Breinbauer, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/607 631/92/96 Adipose Tissue, White Animals Biochemical Engineering Biochemistry Bioorganic Chemistry brief-communication Cell Biology Chemistry Chemistry/Food Science Fatty acids Gene Expression Regulation, Enzymologic Inhibitory Concentration 50 Lipase - antagonists & inhibitors Lipase - genetics Lipase - metabolism Metabolic disorders Mice Mice, Knockout Molecular Structure Molecules Pharmacology Phenylurea Compounds - pharmacology
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