Progastrin Stimulates Colonic Cell Proliferation via CCK2R- and β-Arrestin–Dependent Suppression of BMP2

Background & Aims Progastrin stimulates colonic mucosal proliferation and carcinogenesis through the cholecystokinin 2 receptor (CCK2R)—partly by increasing the number of colonic progenitor cells. However, little is known about the mechanisms by which progastrin stimulates colonic cell prolifera...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2013-10, Vol.145 (4), p.820-830.e10
Hauptverfasser:	Jin, Guangchun, Westphalen, C. Benedikt, Hayakawa, Yoku, Worthley, Daniel L, Asfaha, Samuel, Yang, Xiangdong, Chen, Xiaowei, Si, Yiling, Wang, Hongshan, Tailor, Yagnesh, Friedman, Richard A, Wang, Timothy C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrestins - physiology beta-Arrestin 1 beta-Arrestins BMP Bone Morphogenetic Protein 2 - antagonists & inhibitors Bone Morphogenetic Protein 2 - physiology CCK2R Cell Proliferation - drug effects Colon - cytology Colon - drug effects Gastrins - pharmacology Gastroenterology and Hepatology Mice Mice, Inbred C57BL Progastrin Protein Precursors - pharmacology Receptor, Cholecystokinin B - physiology Signal Transduction Stem Cells - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!