Real-time PCR assay based on the differential expression of microRNAs and protein-coding genes for molecular classification of formalin-fixed paraffin embedded medulloblastomas

Medulloblastoma has recently been found to consist of 4 molecularly and clinically distinct subgroups: WNT, Sonce hedgehog (SHH), Group 3, and Group 4. Deregulated microRNA expression is known to contribute to pathogenesis and has been shown to have diagnostic and prognostic potential in the classif...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2013-12, Vol.15 (12), p.1644-1651
Hauptverfasser:	Kunder, Ratika, Jalali, Rakesh, Sridhar, Epari, Moiyadi, Aliasgar, Goel, Naina, Goel, Atul, Gupta, Tejpal, Krishnatry, Rahul, Kannan, Sadhana, Kurkure, Purna, Deopujari, Chandrashekhar, Shetty, Prakash, Biyani, Naresh, Korshunov, Andrey, Pfister, Stefan M, Northcott, Paul A, Shirsat, Neelam Vishwanath
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Basic and Translational Investigations Case-Control Studies Cerebellar Neoplasms - classification Cerebellar Neoplasms - genetics Cerebellar Neoplasms - mortality Cerebellar Neoplasms - pathology Cerebellum - metabolism Cerebellum - pathology Child Child, Preschool Female Follow-Up Studies Gene Expression Profiling Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Humans Infant Male Medulloblastoma - classification Medulloblastoma - genetics Medulloblastoma - mortality Medulloblastoma - pathology MicroRNAs - genetics Middle Aged Neoplasm Staging Oligonucleotide Array Sequence Analysis Paraffin Embedding Prognosis Real-Time Polymerase Chain Reaction - methods Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Survival Rate Wnt Proteins - genetics Wnt Proteins - metabolism Young Adult
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