NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Promotes Transfer of NEDD8 to Proteasome for Degradation through the P97UFD1/NPL4 Complex

The NEDD8 protein and neddylation levels in cells are modulated by NUB1L or NUB1 through proteasomal degradation, but the underlying molecular mechanism is not well understood. Here, we report that NUB1L down-regulated the protein levels of NEDD8 and neddylation through specifically recognizing NEDD...

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Veröffentlicht in:	The Journal of biological chemistry 2013-10, Vol.288 (43), p.31339-31349
Hauptverfasser:	Liu, Shuai, Yang, Hui, Zhao, Jian, Zhang, Yu-Hang, Song, Ai-Xin, Hu, Hong-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Amino Acid Motifs Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line Cullin 1 Cullin Proteins - genetics Cullin Proteins - metabolism Humans Intracellular Signaling Peptides and Proteins Multiprotein Complexes - genetics Multiprotein Complexes - metabolism NEDD8 NEDD8 Protein Neddylation NUB1L Nuclear Proteins - genetics Nuclear Proteins - metabolism P97/VCp Complex Proteasome Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Protein Degradation Protein Motifs Protein Synthesis and Degradation Protein-Protein Interactions Proteins - genetics Proteins - metabolism Proteolysis SKP Cullin F-Box Protein Ligases - genetics SKP Cullin F-Box Protein Ligases - metabolism Transcription Factors - genetics Transcription Factors - metabolism Ubiquitination Ubiquitins - genetics Ubiquitins - metabolism Valosin Containing Protein
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