Interleukin‐33 overexpression is associated with liver fibrosis in mice and humans

Interleukin‐33 (IL‐33), the most recently identified member of the IL‐1 family, induces synthesis of T Helper 2 (Th2)‐type cytokines via its heterodimeric ST2/IL‐1RAcP receptor. Th2‐type cytokines play an important role in fibrosis; thus, we investigated the role of IL‐33 in liver fibrosis. IL‐33, S...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cellular and molecular medicine 2010-06, Vol.14 (6b), p.1726-1739
Hauptverfasser:	Marvie, Pierrick, Lisbonne, Mariette, L’Helgoualc’h, Annie, Rauch, Michel, Turlin, Bruno, Preisser, Laurence, Bourd‐Boittin, Katia, Théret, Nathalie, Gascan, Hugues, Piquet‐Pellorce, Claire, Samson, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biochemistry, Molecular Biology Biopsy Carcinoma, Hepatocellular Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell culture Cell Nucleus Cell Nucleus - metabolism Cells, Cultured Correlation analysis Cytokines Endothelial Cells Endothelial Cells - metabolism Female Fibrosis Gene expression Gene Expression Regulation Hepatic Stellate Cells Hepatic Stellate Cells - metabolism Hepatitis Hepatocellular carcinoma Hepatocytes Humans IL‐33 Immunoglobulins Inflammation Inflammation - metabolism Inflammation - pathology Interleukin 1 receptors Interleukin-1 Receptor Accessory Protein Interleukin-1 Receptor Accessory Protein - genetics Interleukin-1 Receptor Accessory Protein - metabolism Interleukin-33 Interleukins Interleukins - genetics Interleukins - metabolism Kinases Laboratories Life Sciences Liver Liver - metabolism Liver - pathology Liver cancer Liver Cirrhosis Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Neoplasms Liver Neoplasms - metabolism Liver Neoplasms - pathology Lymphocytes T Male Mice Middle Aged Original Protein Transport Proteins Ribonucleic acid RNA RNA, Messenger RNA, Messenger - genetics RNA, Messenger - metabolism Rodents ST2 Stellate cells Th2 cytokines Tumor necrosis factor-TNF Western blotting
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!