Chagas’ disease: an update on immune mechanisms and therapeutic strategies
• Introduction • Chagas’ disease • Chemotherapy • Immune response in experimental T. cruzi infection • Immune response in human beings infected with T. cruzi • Immune response in the treatment of chagasic infection • The need for new therapeutic alternatives for Chagas’ disease • Conclusions...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2010-06, Vol.14 (6b), p.1373-1384 |
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| creator | Boscardin, Silvia Beatriz Torrecilhas, Ana Claudia Troccoli Manarin, Romina Revelli, Silvia Rey, Elena Gonzalez Tonelli, Renata Rosito Silber, Ariel Mariano |
| description | •
Introduction
•
Chagas’ disease
•
Chemotherapy
•
Immune response in experimental T. cruzi infection
•
Immune response in human beings infected with T. cruzi
•
Immune response in the treatment of chagasic infection
•
The need for new therapeutic alternatives for Chagas’ disease
•
Conclusions
The final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order. Among the pathogenic trypanosomatids, some species are of particular interest due to their medical importance. These species include the agent responsible for Chagas’ disease, Trypanosoma cruzi. Approximately 8 to 10 million people are infected in the Americas, and approximately 40 million are at risk. In the present review, we discuss in detail the immune mechanisms elicited during infection by T. cruzi and the effects of chemotherapy in controlling parasite proliferation and on the host immune system. |
| doi_str_mv | 10.1111/j.1582-4934.2010.01007.x |
| format | Article |
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Introduction
•
Chagas’ disease
•
Chemotherapy
•
Immune response in experimental T. cruzi infection
•
Immune response in human beings infected with T. cruzi
•
Immune response in the treatment of chagasic infection
•
The need for new therapeutic alternatives for Chagas’ disease
•
Conclusions
The final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order. Among the pathogenic trypanosomatids, some species are of particular interest due to their medical importance. These species include the agent responsible for Chagas’ disease, Trypanosoma cruzi. Approximately 8 to 10 million people are infected in the Americas, and approximately 40 million are at risk. In the present review, we discuss in detail the immune mechanisms elicited during infection by T. cruzi and the effects of chemotherapy in controlling parasite proliferation and on the host immune system.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/j.1582-4934.2010.01007.x</identifier><identifier>PMID: 20070438</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Asymptomatic ; Chagas Disease - drug therapy ; Chagas Disease - immunology ; Chagas Disease - parasitology ; Chagas Disease - therapy ; Chagas’ disease ; Chemotherapy ; Chronic illnesses ; Disease ; Enzymes ; Heart failure ; Humans ; Immune response ; Immune system ; immunity ; immunoparasitology ; Infections ; Infectious diseases ; Kinases ; Medical importance ; Medical research ; Mortality ; Nervous system ; Parasites ; Parasitic diseases ; Parasitic protozoa ; Patients ; Protozoa ; Review ; Sterols ; Trypanosoma cruzi ; Trypanosoma cruzi - immunology</subject><ispartof>Journal of cellular and molecular medicine, 2010-06, Vol.14 (6b), p.1373-1384</ispartof><rights>2010 The Authors Journal compilation © 2010 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd</rights><rights>2010. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright Blackwell Publishing Ltd. Jun 2010</rights><rights>2010 The Authors Journal compilation © 2010 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5297-318ad6dad008f934f3fcd7862961a8095560dd8bb9216e4593042d3ad83ae6073</citedby><cites>FETCH-LOGICAL-c5297-318ad6dad008f934f3fcd7862961a8095560dd8bb9216e4593042d3ad83ae6073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829005/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829005/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1582-4934.2010.01007.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20070438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boscardin, Silvia Beatriz</creatorcontrib><creatorcontrib>Torrecilhas, Ana Claudia Troccoli</creatorcontrib><creatorcontrib>Manarin, Romina</creatorcontrib><creatorcontrib>Revelli, Silvia</creatorcontrib><creatorcontrib>Rey, Elena Gonzalez</creatorcontrib><creatorcontrib>Tonelli, Renata Rosito</creatorcontrib><creatorcontrib>Silber, Ariel Mariano</creatorcontrib><title>Chagas’ disease: an update on immune mechanisms and therapeutic strategies</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>•
Introduction
•
Chagas’ disease
•
Chemotherapy
•
Immune response in experimental T. cruzi infection
•
Immune response in human beings infected with T. cruzi
•
Immune response in the treatment of chagasic infection
•
The need for new therapeutic alternatives for Chagas’ disease
•
Conclusions
The final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order. Among the pathogenic trypanosomatids, some species are of particular interest due to their medical importance. These species include the agent responsible for Chagas’ disease, Trypanosoma cruzi. Approximately 8 to 10 million people are infected in the Americas, and approximately 40 million are at risk. In the present review, we discuss in detail the immune mechanisms elicited during infection by T. cruzi and the effects of chemotherapy in controlling parasite proliferation and on the host immune system.</description><subject>Asymptomatic</subject><subject>Chagas Disease - drug therapy</subject><subject>Chagas Disease - immunology</subject><subject>Chagas Disease - parasitology</subject><subject>Chagas Disease - therapy</subject><subject>Chagas’ disease</subject><subject>Chemotherapy</subject><subject>Chronic illnesses</subject><subject>Disease</subject><subject>Enzymes</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>immunity</subject><subject>immunoparasitology</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Kinases</subject><subject>Medical importance</subject><subject>Medical research</subject><subject>Mortality</subject><subject>Nervous system</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Parasitic protozoa</subject><subject>Patients</subject><subject>Protozoa</subject><subject>Review</subject><subject>Sterols</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - immunology</subject><issn>1582-1838</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNUdtuEzEQtVARvcAvIIs-8JQwttdem4dKVUShVSpe4Nly1rOJo72E9S60b_2N_l6_pN42DRepEpYsj2bOnDnjQwhlMGXpfFhPmdR8khmRTTmkbLqQT69ekINdYW8bMy30PjmMcQ0gFBPmFdnnCQ2Z0AdkPlu5pYt3N7fUh4gu4kfqGjpsvOuRtg0NdT00SGssVq4JsY6p7Gm_ws5tcOhDQWPfJewyYHxNXpauivhm-x6R72efvs2-TOZfP5_PTueTQnKTTwTTzivvPIAuk9JSlIXPteJGMafBSKnAe71YGM4UZtIIyLgXzmvhUEEujsjJI-9mWNToC2yShMpuulC77tq2Lti_K01Y2WX70wrNDYBMBO-3BF37Y8DY2zrEAqvKNdgO0eaZAaa1Hke9-we5boeuSdvZXOZKcsZVAh0_BxKQS6M4N-NQ_YgqujbGDsudYAZ2tNWu7eiYHd2zo632wVZ7lVrf_rnwrvHJx98_8itUeP3fxPZidnk5huIechqxAA</recordid><startdate>201006</startdate><enddate>201006</enddate><creator>Boscardin, Silvia Beatriz</creator><creator>Torrecilhas, Ana Claudia Troccoli</creator><creator>Manarin, Romina</creator><creator>Revelli, Silvia</creator><creator>Rey, Elena Gonzalez</creator><creator>Tonelli, Renata Rosito</creator><creator>Silber, Ariel Mariano</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201006</creationdate><title>Chagas’ disease: an update on immune mechanisms and therapeutic strategies</title><author>Boscardin, Silvia Beatriz ; Torrecilhas, Ana Claudia Troccoli ; Manarin, Romina ; Revelli, Silvia ; Rey, Elena Gonzalez ; Tonelli, Renata Rosito ; Silber, Ariel Mariano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5297-318ad6dad008f934f3fcd7862961a8095560dd8bb9216e4593042d3ad83ae6073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Asymptomatic</topic><topic>Chagas Disease - drug therapy</topic><topic>Chagas Disease - immunology</topic><topic>Chagas Disease - parasitology</topic><topic>Chagas Disease - therapy</topic><topic>Chagas’ disease</topic><topic>Chemotherapy</topic><topic>Chronic illnesses</topic><topic>Disease</topic><topic>Enzymes</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>immunity</topic><topic>immunoparasitology</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Kinases</topic><topic>Medical importance</topic><topic>Medical research</topic><topic>Mortality</topic><topic>Nervous system</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>Parasitic protozoa</topic><topic>Patients</topic><topic>Protozoa</topic><topic>Review</topic><topic>Sterols</topic><topic>Trypanosoma cruzi</topic><topic>Trypanosoma cruzi - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boscardin, Silvia Beatriz</creatorcontrib><creatorcontrib>Torrecilhas, Ana Claudia Troccoli</creatorcontrib><creatorcontrib>Manarin, Romina</creatorcontrib><creatorcontrib>Revelli, Silvia</creatorcontrib><creatorcontrib>Rey, Elena Gonzalez</creatorcontrib><creatorcontrib>Tonelli, Renata Rosito</creatorcontrib><creatorcontrib>Silber, Ariel Mariano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Journals (ProQuest Database)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Boscardin, Silvia Beatriz</au><au>Torrecilhas, Ana Claudia Troccoli</au><au>Manarin, Romina</au><au>Revelli, Silvia</au><au>Rey, Elena Gonzalez</au><au>Tonelli, Renata Rosito</au><au>Silber, Ariel Mariano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chagas’ disease: an update on immune mechanisms and therapeutic strategies</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2010-06</date><risdate>2010</risdate><volume>14</volume><issue>6b</issue><spage>1373</spage><epage>1384</epage><pages>1373-1384</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>•
Introduction
•
Chagas’ disease
•
Chemotherapy
•
Immune response in experimental T. cruzi infection
•
Immune response in human beings infected with T. cruzi
•
Immune response in the treatment of chagasic infection
•
The need for new therapeutic alternatives for Chagas’ disease
•
Conclusions
The final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order. Among the pathogenic trypanosomatids, some species are of particular interest due to their medical importance. These species include the agent responsible for Chagas’ disease, Trypanosoma cruzi. Approximately 8 to 10 million people are infected in the Americas, and approximately 40 million are at risk. In the present review, we discuss in detail the immune mechanisms elicited during infection by T. cruzi and the effects of chemotherapy in controlling parasite proliferation and on the host immune system.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20070438</pmid><doi>10.1111/j.1582-4934.2010.01007.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Asymptomatic Chagas Disease - drug therapy Chagas Disease - immunology Chagas Disease - parasitology Chagas Disease - therapy Chagas’ disease Chemotherapy Chronic illnesses Disease Enzymes Heart failure Humans Immune response Immune system immunity immunoparasitology Infections Infectious diseases Kinases Medical importance Medical research Mortality Nervous system Parasites Parasitic diseases Parasitic protozoa Patients Protozoa Review Sterols Trypanosoma cruzi Trypanosoma cruzi - immunology |
| title | Chagas’ disease: an update on immune mechanisms and therapeutic strategies |
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