Yin Yang 1 Plays an Essential Role in Breast Cancer and Negatively Regulates p27

Yin Yang 1 (YY1) is highly expressed in various types of cancers and regulates tumorigenesis through multiple pathways. In the present study, we evaluated YY1 expression levels in breast cancer cell lines, a breast cancer TMA, and two gene arrays. We observed that, compared with normal samples, YY1...

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Veröffentlicht in:	The American journal of pathology 2012-05, Vol.180 (5), p.2120-2133
Hauptverfasser:	Wan, Meimei, Huang, Weiwei, Kute, Timothy E, Miller, Lance D, Zhang, Qiang, Hatcher, Heather, Wang, Jingxuan, Stovall, Daniel B, Russell, Gregory B, Cao, Paul D, Deng, Zhiyong, Wang, Wei, Zhang, Qingyuan, Lei, Ming, Torti, Suzy V, Akman, Steven A, Sui, Guangchao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Cycle - physiology Cell Movement - physiology Cell Proliferation Cell Shape - physiology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Female Gene Expression Regulation, Neoplastic - physiology Gene Knockdown Techniques Gynecology. Andrology. Obstetrics Humans Investigative techniques, diagnostic techniques (general aspects) Mammary gland diseases Medical sciences Mice Mice, Nude Neoplasm Invasiveness Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasm Proteins - physiology Neoplasm Transplantation Neoplastic Stem Cells - pathology Oligonucleotide Array Sequence Analysis - methods Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Protein Processing, Post-Translational - physiology Real-Time Polymerase Chain Reaction - methods Regular Transplantation, Heterologous Tumor Cells, Cultured Tumors Up-Regulation - physiology YY1 Transcription Factor - genetics YY1 Transcription Factor - metabolism YY1 Transcription Factor - physiology
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