Pathogen-Specific Treg Cells Expand Early during Mycobacterium tuberculosis Infection but Are Later Eliminated in Response to Interleukin-12

Thymically derived Foxp3+ regulatory T (Treg) cells have a propensity to recognize self-peptide:MHC complexes, but their ability to respond to epitope-defined foreign antigens during infectious challenge has not been demonstrated. Here we show that pulmonary infection with Mycobacterium tuberculosis...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2013-06, Vol.38 (6), p.1261-1270
Hauptverfasser:	Shafiani, Shahin, Dinh, Crystal, Ertelt, James M., Moguche, Albanus O., Siddiqui, Imran, Smigiel, Kate S., Sharma, Pawan, Campbell, Daniel J., Way, Sing Sing, Urdahl, Kevin B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - immunology Bacterial Proteins - immunology Cell Proliferation Cells, Cultured Clonal Deletion Epitopes, T-Lymphocyte - immunology Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Immune Evasion Interleukin-12 - immunology Listeria monocytogenes Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Knockout Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Peptide Fragments - immunology T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - microbiology Th1 Cells - immunology Thymus Gland - pathology Tuberculosis, Pulmonary - immunology
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