A randomized, controlled cross-over trial of dermally-applied lavender (Lavandula angustifolia) oil as a treatment of agitated behaviour in dementia
Lavender essential oil shows evidence of sedative properties in neurophysiological and animal studies but clinical trials of its effectiveness as a treatment of agitation in people with dementia have shown mixed results. Study methods have varied widely, however, making comparisons hazardous. To hel...
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| Veröffentlicht in: | BMC complementary and alternative medicine 2013-11, Vol.13 (1), p.315-315, Article 315 |
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| creator | O'Connor, Daniel W Eppingstall, Barbara Taffe, John van der Ploeg, Eva S |
| description | Lavender essential oil shows evidence of sedative properties in neurophysiological and animal studies but clinical trials of its effectiveness as a treatment of agitation in people with dementia have shown mixed results. Study methods have varied widely, however, making comparisons hazardous. To help remedy previous methodological shortcomings, we delivered high grade lavender oil in specified amounts to nursing home residents whose agitated behaviours were recorded objectively.
64 nursing home residents with frequent physically agitated behaviours were entered into a randomized, single-blind cross-over trial of dermally-applied, neurophysiologically active, high purity 30% lavender oil versus an inactive control oil. A blinded observer counted the presence or absence of target behaviours and rated participants' predominant affect during each minute for 30 minutes prior to exposure and for 60 minutes afterwards.
Lavender oil did not prove superior to the control oil in reducing the frequency of physically agitated behaviours or in improving participants' affect.
Studies of essential oils are constrained by their variable formulations and uncertain pharmacokinetics and so optimal dosing and delivery regimens remain speculative. Notwithstanding this, topically delivered, high strength, pure lavender oil had no discernible effect on affect and behaviour in a well-defined clinical sample.
Australian and New Zealand Clinical Trials Registry (ACTRN 12609000569202). |
| doi_str_mv | 10.1186/1472-6882-13-315 |
| format | Article |
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64 nursing home residents with frequent physically agitated behaviours were entered into a randomized, single-blind cross-over trial of dermally-applied, neurophysiologically active, high purity 30% lavender oil versus an inactive control oil. A blinded observer counted the presence or absence of target behaviours and rated participants' predominant affect during each minute for 30 minutes prior to exposure and for 60 minutes afterwards.
Lavender oil did not prove superior to the control oil in reducing the frequency of physically agitated behaviours or in improving participants' affect.
Studies of essential oils are constrained by their variable formulations and uncertain pharmacokinetics and so optimal dosing and delivery regimens remain speculative. Notwithstanding this, topically delivered, high strength, pure lavender oil had no discernible effect on affect and behaviour in a well-defined clinical sample.
Australian and New Zealand Clinical Trials Registry (ACTRN 12609000569202).</description><identifier>ISSN: 1472-6882</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/1472-6882-13-315</identifier><identifier>PMID: 24219098</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Aged, 80 and over ; Agitation ; Animals ; Aromatherapy ; Australia ; Care and treatment ; Cross-Over Studies ; Dementia ; Dementia - complications ; Dementia - psychology ; Essences and essential oils ; Female ; Health aspects ; Humans ; Lavandula ; Lavandula - chemistry ; Lavenders ; Male ; Medical research ; Medicine, Experimental ; Neurophysiology ; Nursing home patients ; Oils, Volatile - administration & dosage ; Plant Oils - administration & dosage ; Psychomotor Agitation - drug therapy ; Psychomotor Agitation - etiology ; Single-Blind Method ; Transdermal medication ; Treatment Outcome</subject><ispartof>BMC complementary and alternative medicine, 2013-11, Vol.13 (1), p.315-315, Article 315</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 O'Connor et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 O’Connor et al.; licensee BioMed Central Ltd. 2013 O’Connor et al.; licensee BioMed Central Ltd.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b615t-68e1b77bcec327d2702d0543b1a12f304d50a59ad13c37fe99055e7dc7bb73763</citedby><cites>FETCH-LOGICAL-b615t-68e1b77bcec327d2702d0543b1a12f304d50a59ad13c37fe99055e7dc7bb73763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827620/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827620/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24219098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Connor, Daniel W</creatorcontrib><creatorcontrib>Eppingstall, Barbara</creatorcontrib><creatorcontrib>Taffe, John</creatorcontrib><creatorcontrib>van der Ploeg, Eva S</creatorcontrib><title>A randomized, controlled cross-over trial of dermally-applied lavender (Lavandula angustifolia) oil as a treatment of agitated behaviour in dementia</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Altern Med</addtitle><description>Lavender essential oil shows evidence of sedative properties in neurophysiological and animal studies but clinical trials of its effectiveness as a treatment of agitation in people with dementia have shown mixed results. Study methods have varied widely, however, making comparisons hazardous. To help remedy previous methodological shortcomings, we delivered high grade lavender oil in specified amounts to nursing home residents whose agitated behaviours were recorded objectively.
64 nursing home residents with frequent physically agitated behaviours were entered into a randomized, single-blind cross-over trial of dermally-applied, neurophysiologically active, high purity 30% lavender oil versus an inactive control oil. A blinded observer counted the presence or absence of target behaviours and rated participants' predominant affect during each minute for 30 minutes prior to exposure and for 60 minutes afterwards.
Lavender oil did not prove superior to the control oil in reducing the frequency of physically agitated behaviours or in improving participants' affect.
Studies of essential oils are constrained by their variable formulations and uncertain pharmacokinetics and so optimal dosing and delivery regimens remain speculative. Notwithstanding this, topically delivered, high strength, pure lavender oil had no discernible effect on affect and behaviour in a well-defined clinical sample.
Australian and New Zealand Clinical Trials Registry (ACTRN 12609000569202).</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Agitation</subject><subject>Animals</subject><subject>Aromatherapy</subject><subject>Australia</subject><subject>Care and treatment</subject><subject>Cross-Over Studies</subject><subject>Dementia</subject><subject>Dementia - complications</subject><subject>Dementia - psychology</subject><subject>Essences and essential oils</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Lavandula</subject><subject>Lavandula - chemistry</subject><subject>Lavenders</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Neurophysiology</subject><subject>Nursing home patients</subject><subject>Oils, Volatile - administration & dosage</subject><subject>Plant Oils - administration & dosage</subject><subject>Psychomotor Agitation - drug therapy</subject><subject>Psychomotor Agitation - etiology</subject><subject>Single-Blind Method</subject><subject>Transdermal medication</subject><subject>Treatment Outcome</subject><issn>1472-6882</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kl2L1DAUhoso7ofeeyUBQVawaz7apr0RhsEvGPBGr8Npm85kSZMxSQfW3-EP3lNnHWdkJRcJ57znSXLek2UvGL1mrK7esULyvKprnjORC1Y-ys4PocdH57PsIsYbSpmsWfE0O-MFZw1t6vPs14IEcL0fzU_dvyWddyl4a3VPuuBjzP1OB5KCAUv8QHodRrD2Noft1hoUWdhph1FytYIdciYLBNx6iskM3hp4Q7yxBCIBhGhIo3ZpBsHaJEgIaPUGdsZPgRiH-Dlv4Fn2ZAAb9fP7_TL7_vHDt-XnfPX105flYpW3FSsT_kyzVsq2053gsueS8p6WhWgZMD4IWvQlhbKBnolOyEE3DS1LLftOtq0UshKX2fs9dzu1o-47vDyAVdtgRgi3yoNRpxlnNmrtd0rUXFacImC5B7TG_wdwmun8qGZX1OyKYkKhaUi5un9G8D8mHZMaTey0teC0nyIWNLxiNa0ESl_9I73B3jlsEqrKuhJUUP5XtQarlXGDx8u7GaoWpSgqUdRFjarrB1S40AaDg6AHg_GTgtdHBRsNNm2it1My3sVTId0Lf89Q0MOhI4yqeXAf6sHLYysOBX8mVdwBXHrpeA</recordid><startdate>20131113</startdate><enddate>20131113</enddate><creator>O'Connor, Daniel W</creator><creator>Eppingstall, Barbara</creator><creator>Taffe, John</creator><creator>van der Ploeg, Eva S</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20131113</creationdate><title>A randomized, controlled cross-over trial of dermally-applied lavender (Lavandula angustifolia) oil as a treatment of agitated behaviour in dementia</title><author>O'Connor, Daniel W ; Eppingstall, Barbara ; Taffe, John ; van der Ploeg, Eva S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b615t-68e1b77bcec327d2702d0543b1a12f304d50a59ad13c37fe99055e7dc7bb73763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Agitation</topic><topic>Animals</topic><topic>Aromatherapy</topic><topic>Australia</topic><topic>Care and treatment</topic><topic>Cross-Over Studies</topic><topic>Dementia</topic><topic>Dementia - complications</topic><topic>Dementia - psychology</topic><topic>Essences and essential oils</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Lavandula</topic><topic>Lavandula - chemistry</topic><topic>Lavenders</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Neurophysiology</topic><topic>Nursing home patients</topic><topic>Oils, Volatile - administration & dosage</topic><topic>Plant Oils - administration & dosage</topic><topic>Psychomotor Agitation - drug therapy</topic><topic>Psychomotor Agitation - etiology</topic><topic>Single-Blind Method</topic><topic>Transdermal medication</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>O'Connor, Daniel W</creatorcontrib><creatorcontrib>Eppingstall, Barbara</creatorcontrib><creatorcontrib>Taffe, John</creatorcontrib><creatorcontrib>van der Ploeg, Eva S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Connor, Daniel W</au><au>Eppingstall, Barbara</au><au>Taffe, John</au><au>van der Ploeg, Eva S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A randomized, controlled cross-over trial of dermally-applied lavender (Lavandula angustifolia) oil as a treatment of agitated behaviour in dementia</atitle><jtitle>BMC complementary and alternative medicine</jtitle><addtitle>BMC Complement Altern Med</addtitle><date>2013-11-13</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>315</spage><epage>315</epage><pages>315-315</pages><artnum>315</artnum><issn>1472-6882</issn><eissn>1472-6882</eissn><abstract>Lavender essential oil shows evidence of sedative properties in neurophysiological and animal studies but clinical trials of its effectiveness as a treatment of agitation in people with dementia have shown mixed results. Study methods have varied widely, however, making comparisons hazardous. To help remedy previous methodological shortcomings, we delivered high grade lavender oil in specified amounts to nursing home residents whose agitated behaviours were recorded objectively.
64 nursing home residents with frequent physically agitated behaviours were entered into a randomized, single-blind cross-over trial of dermally-applied, neurophysiologically active, high purity 30% lavender oil versus an inactive control oil. A blinded observer counted the presence or absence of target behaviours and rated participants' predominant affect during each minute for 30 minutes prior to exposure and for 60 minutes afterwards.
Lavender oil did not prove superior to the control oil in reducing the frequency of physically agitated behaviours or in improving participants' affect.
Studies of essential oils are constrained by their variable formulations and uncertain pharmacokinetics and so optimal dosing and delivery regimens remain speculative. Notwithstanding this, topically delivered, high strength, pure lavender oil had no discernible effect on affect and behaviour in a well-defined clinical sample.
Australian and New Zealand Clinical Trials Registry (ACTRN 12609000569202).</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24219098</pmid><doi>10.1186/1472-6882-13-315</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC complementary and alternative medicine, 2013-11, Vol.13 (1), p.315-315, Article 315 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; PubMed Central |
| subjects | Aged Aged, 80 and over Agitation Animals Aromatherapy Australia Care and treatment Cross-Over Studies Dementia Dementia - complications Dementia - psychology Essences and essential oils Female Health aspects Humans Lavandula Lavandula - chemistry Lavenders Male Medical research Medicine, Experimental Neurophysiology Nursing home patients Oils, Volatile - administration & dosage Plant Oils - administration & dosage Psychomotor Agitation - drug therapy Psychomotor Agitation - etiology Single-Blind Method Transdermal medication Treatment Outcome |
| title | A randomized, controlled cross-over trial of dermally-applied lavender (Lavandula angustifolia) oil as a treatment of agitated behaviour in dementia |
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