Significance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL

We studied the significance of four hydrophobic residues within the 225-230 region of apoA-I on its structure and functions and their contribution to the biogenesis of HDL. Adenovirus-mediated gene transfer of an apoA-I[F225A/V227A/F229A/L230A] mutant in apoA-I⁻/⁻ mice decreased plasma cholesterol,...

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Veröffentlicht in:	Journal of lipid research 2013-12, Vol.54 (12), p.3293-3302
Hauptverfasser:	Fotakis, Panagiotis, Tiniakou, Ioanna, Kateifides, Andreas K, Gkolfinopoulou, Christina, Chroni, Angeliki, Stratikos, Efstratios, Zannis, Vassilis I, Kardassis, Dimitris
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Apolipoprotein A-I - blood Apolipoprotein A-I - chemistry Apolipoprotein A-I - genetics Apolipoprotein A-I - metabolism Chemical Phenomena HEK293 Cells Humans Hydrophobic and Hydrophilic Interactions Lipoproteins, HDL - biosynthesis Mice Mutation
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