Caveolin-1 is a negative regulator of MMP-1 gene expression in human dermal fibroblasts via inhibition of Erk1/2/Ets1 signaling pathway

Abstract Background Caveolar raft domains, also termed caveolae, are flask shaped invaginations that require the expression of the structural protein caveolin-1 (cav-1). Matrix metalloproteinase 1 (MMP-1) is a collagenase capable of degrading insoluble triple helical collagens. Deregulation of MMP-1...

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Veröffentlicht in:	Journal of dermatological science 2011-12, Vol.64 (3), p.210-216
Hauptverfasser:	Haines, Paul, Samuel, Glady H, Cohen, Heather, Trojanowska, Maria, Bujor, Andreea M
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Caveolin 1 - genetics Caveolin 1 - metabolism Caveolin-1 Cells, Cultured Dermatology Dermis - cytology Dermis - drug effects Dermis - enzymology Extracellular matrix Fibroblasts - drug effects Fibroblasts - enzymology Gene Expression Regulation, Enzymologic Humans JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - metabolism Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - metabolism MMP-1 Phosphorylation Protein Kinase Inhibitors - pharmacology Proto-Oncogene Protein c-ets-1 - metabolism Real-Time Polymerase Chain Reaction RNA Interference RNA, Messenger - metabolism Signal Transduction Sphingomyelin Phosphodiesterase - genetics Sphingomyelin Phosphodiesterase - metabolism Transfection
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