Highly Z‑Selective and Enantioselective Ring-Opening/Cross-Metathesis Catalyzed by a Resolved Stereogenic-at-Ru Complex

The synthesis of a ruthenium complex that catalyzes Z-selective (up to 98% Z) asymmetric ring-opening/cross-metathesis with high enantioselectivity (up to 95% ee) is reported. The synthesis of the catalyst features the resolution of a chelating N-heterocyclic carbene complex by ligand substitution w...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-07, Vol.135 (28), p.10183-10185
Hauptverfasser:	Hartung, John, Grubbs, Robert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis catalysts enantiomers Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Ligands Methane - analogs & derivatives Methane - chemical synthesis Methane - chemistry Models, Molecular Molecular Conformation Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry ruthenium Ruthenium - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	The synthesis of a ruthenium complex that catalyzes Z-selective (up to 98% Z) asymmetric ring-opening/cross-metathesis with high enantioselectivity (up to 95% ee) is reported. The synthesis of the catalyst features the resolution of a chelating N-heterocyclic carbene complex by ligand substitution with a chiral carboxylate.
ISSN:	0002-7863 1520-5126 1520-5126
DOI:	10.1021/ja4046422