Respiratory and Auditory Cortical Processing in Children with Obstructive Sleep Apnea Syndrome
Children with obstructive sleep apnea syndrome (OSAS) have impaired cortical processing of respiratory afferent stimuli, manifested by blunted sleep respiratory-related evoked potentials (RREP). However, whether this impairment is limited to respiratory stimuli, or reversible after successful treatm...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2013-10, Vol.188 (7), p.852-857 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | JINGTAO HUANG MARCUS, Carole L DAVENPORT, Paul W COLRAIN, Ian M GALLAGHER, Paul R TAPIA, Ignacio E |
| description | Children with obstructive sleep apnea syndrome (OSAS) have impaired cortical processing of respiratory afferent stimuli, manifested by blunted sleep respiratory-related evoked potentials (RREP). However, whether this impairment is limited to respiratory stimuli, or reversible after successful treatment, is unknown. We hypothesized that, during sleep, children with OSAS have (1) abnormal RREP, (2) normal cortical processing of nonrespiratory stimuli, and (3) persistence of abnormal RREP after treatment.
To measure sleep RREP and auditory evoked potentials in normal control subjects and children with OSAS before and after treatment.
Twenty-four children with OSAS and 24 control subjects were tested during N3 sleep. Thirteen children with OSAS repeated testing 4-6 months after adenotonsillectomy.
RREP were blunted in OSAS compared with control subjects (N350 at Cz -27 ± 15.5 vs. -47.4 ± 28.5 μV; P = 0.019), and did not improve after OSAS treatment (N350 at Cz pretreatment -25.1 ± 7.4 vs. -29.8 ± 8.1 post-treatment). Auditory evoked potentials were similar in OSAS and control subjects at baseline (N350 at Cz -58 ± 33.1 vs. -66 ± 31.1 μV), and did not change after treatment (N350 at Cz -67.5 ± 36.8 vs. -65.5 ± 20.3).
Children with OSAS have persistent primary or irreversible respiratory afferent cortical processing deficits during sleep that could put them at risk of OSAS recurrence. OSAS does not seem to affect the cortical processing of nonrespiratory (auditory) afferent stimuli during sleep. |
| doi_str_mv | 10.1164/rccm.201307-1257OC |
| format | Article |
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To measure sleep RREP and auditory evoked potentials in normal control subjects and children with OSAS before and after treatment.
Twenty-four children with OSAS and 24 control subjects were tested during N3 sleep. Thirteen children with OSAS repeated testing 4-6 months after adenotonsillectomy.
RREP were blunted in OSAS compared with control subjects (N350 at Cz -27 ± 15.5 vs. -47.4 ± 28.5 μV; P = 0.019), and did not improve after OSAS treatment (N350 at Cz pretreatment -25.1 ± 7.4 vs. -29.8 ± 8.1 post-treatment). Auditory evoked potentials were similar in OSAS and control subjects at baseline (N350 at Cz -58 ± 33.1 vs. -66 ± 31.1 μV), and did not change after treatment (N350 at Cz -67.5 ± 36.8 vs. -65.5 ± 20.3).
Children with OSAS have persistent primary or irreversible respiratory afferent cortical processing deficits during sleep that could put them at risk of OSAS recurrence. OSAS does not seem to affect the cortical processing of nonrespiratory (auditory) afferent stimuli during sleep.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.201307-1257OC</identifier><identifier>PMID: 23947422</identifier><language>eng</language><publisher>New York, NY: American Thoracic Society</publisher><subject>Adenoidectomy ; Adolescent ; Afferent Pathways - physiopathology ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Auditory Cortex - physiology ; Biological and medical sciences ; Case-Control Studies ; Child ; Evoked Potentials - physiology ; Female ; Humans ; Intensive care medicine ; Male ; Medical sciences ; Nervous system ; Pediatrics ; Philadelphia ; Pneumology ; Polysomnography ; Respiratory System - innervation ; Respiratory System - physiopathology ; Respiratory System - surgery ; Respiratory system : syndromes and miscellaneous diseases ; Sleep apnea ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - physiopathology ; Sleep Apnea, Obstructive - surgery ; Statistical analysis ; Tonsillectomy ; Treatment Outcome ; Turbinates - surgery</subject><ispartof>American journal of respiratory and critical care medicine, 2013-10, Vol.188 (7), p.852-857</ispartof><rights>2014 INIST-CNRS</rights><rights>Copyright American Thoracic Society Oct 1, 2013</rights><rights>Copyright © 2013 by the American Thoracic Society 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-5dd916f98230ce6e28c46b64e2f6b4fbcdbbd7a76af9c8f743dd53d428d1d48d3</citedby><cites>FETCH-LOGICAL-c460t-5dd916f98230ce6e28c46b64e2f6b4fbcdbbd7a76af9c8f743dd53d428d1d48d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4025,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27805784$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23947422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JINGTAO HUANG</creatorcontrib><creatorcontrib>MARCUS, Carole L</creatorcontrib><creatorcontrib>DAVENPORT, Paul W</creatorcontrib><creatorcontrib>COLRAIN, Ian M</creatorcontrib><creatorcontrib>GALLAGHER, Paul R</creatorcontrib><creatorcontrib>TAPIA, Ignacio E</creatorcontrib><title>Respiratory and Auditory Cortical Processing in Children with Obstructive Sleep Apnea Syndrome</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Children with obstructive sleep apnea syndrome (OSAS) have impaired cortical processing of respiratory afferent stimuli, manifested by blunted sleep respiratory-related evoked potentials (RREP). However, whether this impairment is limited to respiratory stimuli, or reversible after successful treatment, is unknown. We hypothesized that, during sleep, children with OSAS have (1) abnormal RREP, (2) normal cortical processing of nonrespiratory stimuli, and (3) persistence of abnormal RREP after treatment.
To measure sleep RREP and auditory evoked potentials in normal control subjects and children with OSAS before and after treatment.
Twenty-four children with OSAS and 24 control subjects were tested during N3 sleep. Thirteen children with OSAS repeated testing 4-6 months after adenotonsillectomy.
RREP were blunted in OSAS compared with control subjects (N350 at Cz -27 ± 15.5 vs. -47.4 ± 28.5 μV; P = 0.019), and did not improve after OSAS treatment (N350 at Cz pretreatment -25.1 ± 7.4 vs. -29.8 ± 8.1 post-treatment). Auditory evoked potentials were similar in OSAS and control subjects at baseline (N350 at Cz -58 ± 33.1 vs. -66 ± 31.1 μV), and did not change after treatment (N350 at Cz -67.5 ± 36.8 vs. -65.5 ± 20.3).
Children with OSAS have persistent primary or irreversible respiratory afferent cortical processing deficits during sleep that could put them at risk of OSAS recurrence. OSAS does not seem to affect the cortical processing of nonrespiratory (auditory) afferent stimuli during sleep.</description><subject>Adenoidectomy</subject><subject>Adolescent</subject><subject>Afferent Pathways - physiopathology</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Auditory Cortex - physiology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Evoked Potentials - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Pediatrics</subject><subject>Philadelphia</subject><subject>Pneumology</subject><subject>Polysomnography</subject><subject>Respiratory System - innervation</subject><subject>Respiratory System - physiopathology</subject><subject>Respiratory System - surgery</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Sleep Apnea, Obstructive - surgery</subject><subject>Statistical analysis</subject><subject>Tonsillectomy</subject><subject>Treatment Outcome</subject><subject>Turbinates - surgery</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkV1rFDEUhgex2Fr9A15IQITeTM3XTDI3wjJYFQpbrIJXhkxyppsyk4zJTGX_vVl3W6tX-XrOS16eonhF8DkhNX8XjRnPKSYMi5LQSqzbJ8UJqVhV8kbgp3mPBSs5b74fF89TusWYUEnws-KYsoYLTulJ8eMLpMlFPYe4RdpbtFqs-3NoQ5yd0QO6isFASs7fIOdRu3GDjeDRLzdv0LpLc1zM7O4AXQ8AE1pNHjS63nobwwgviqNeDwleHtbT4tvFh6_tp_Jy_fFzu7osDa_xXFbWNqTuG0kZNlADlfm-qznQvu543xnbdVZoUeu-MbIXnFlbMcuptMRyadlp8X6fOy3dCNaAn6Me1BTdqONWBe3Uvy_ebdRNuFNM0pqKKgecHQJi-LlAmtXokoFh0B7CkhThnDEpBSUZffMfehuW6HO9HdWQXYkmU3RPmRhSitA_fIZgtdOndvrUXp_a68tDrx_XeBi595WBtwdAp-ymj9obl_5yQuJKSM5-A3kvpk0</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>JINGTAO HUANG</creator><creator>MARCUS, Carole L</creator><creator>DAVENPORT, Paul W</creator><creator>COLRAIN, Ian M</creator><creator>GALLAGHER, Paul R</creator><creator>TAPIA, Ignacio E</creator><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131001</creationdate><title>Respiratory and Auditory Cortical Processing in Children with Obstructive Sleep Apnea Syndrome</title><author>JINGTAO HUANG ; MARCUS, Carole L ; DAVENPORT, Paul W ; COLRAIN, Ian M ; GALLAGHER, Paul R ; TAPIA, Ignacio E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-5dd916f98230ce6e28c46b64e2f6b4fbcdbbd7a76af9c8f743dd53d428d1d48d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenoidectomy</topic><topic>Adolescent</topic><topic>Afferent Pathways - physiopathology</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Auditory Cortex - physiology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Evoked Potentials - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Pediatrics</topic><topic>Philadelphia</topic><topic>Pneumology</topic><topic>Polysomnography</topic><topic>Respiratory System - innervation</topic><topic>Respiratory System - physiopathology</topic><topic>Respiratory System - surgery</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Sleep Apnea, Obstructive - surgery</topic><topic>Statistical analysis</topic><topic>Tonsillectomy</topic><topic>Treatment Outcome</topic><topic>Turbinates - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JINGTAO HUANG</creatorcontrib><creatorcontrib>MARCUS, Carole L</creatorcontrib><creatorcontrib>DAVENPORT, Paul W</creatorcontrib><creatorcontrib>COLRAIN, Ian M</creatorcontrib><creatorcontrib>GALLAGHER, Paul R</creatorcontrib><creatorcontrib>TAPIA, Ignacio E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JINGTAO HUANG</au><au>MARCUS, Carole L</au><au>DAVENPORT, Paul W</au><au>COLRAIN, Ian M</au><au>GALLAGHER, Paul R</au><au>TAPIA, Ignacio E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Respiratory and Auditory Cortical Processing in Children with Obstructive Sleep Apnea Syndrome</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>188</volume><issue>7</issue><spage>852</spage><epage>857</epage><pages>852-857</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Children with obstructive sleep apnea syndrome (OSAS) have impaired cortical processing of respiratory afferent stimuli, manifested by blunted sleep respiratory-related evoked potentials (RREP). However, whether this impairment is limited to respiratory stimuli, or reversible after successful treatment, is unknown. We hypothesized that, during sleep, children with OSAS have (1) abnormal RREP, (2) normal cortical processing of nonrespiratory stimuli, and (3) persistence of abnormal RREP after treatment.
To measure sleep RREP and auditory evoked potentials in normal control subjects and children with OSAS before and after treatment.
Twenty-four children with OSAS and 24 control subjects were tested during N3 sleep. Thirteen children with OSAS repeated testing 4-6 months after adenotonsillectomy.
RREP were blunted in OSAS compared with control subjects (N350 at Cz -27 ± 15.5 vs. -47.4 ± 28.5 μV; P = 0.019), and did not improve after OSAS treatment (N350 at Cz pretreatment -25.1 ± 7.4 vs. -29.8 ± 8.1 post-treatment). Auditory evoked potentials were similar in OSAS and control subjects at baseline (N350 at Cz -58 ± 33.1 vs. -66 ± 31.1 μV), and did not change after treatment (N350 at Cz -67.5 ± 36.8 vs. -65.5 ± 20.3).
Children with OSAS have persistent primary or irreversible respiratory afferent cortical processing deficits during sleep that could put them at risk of OSAS recurrence. OSAS does not seem to affect the cortical processing of nonrespiratory (auditory) afferent stimuli during sleep.</abstract><cop>New York, NY</cop><pub>American Thoracic Society</pub><pmid>23947422</pmid><doi>10.1164/rccm.201307-1257OC</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of respiratory and critical care medicine, 2013-10, Vol.188 (7), p.852-857 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload; American Thoracic Society (ATS) Journals Online; Alma/SFX Local Collection |
| subjects | Adenoidectomy Adolescent Afferent Pathways - physiopathology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Auditory Cortex - physiology Biological and medical sciences Case-Control Studies Child Evoked Potentials - physiology Female Humans Intensive care medicine Male Medical sciences Nervous system Pediatrics Philadelphia Pneumology Polysomnography Respiratory System - innervation Respiratory System - physiopathology Respiratory System - surgery Respiratory system : syndromes and miscellaneous diseases Sleep apnea Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - physiopathology Sleep Apnea, Obstructive - surgery Statistical analysis Tonsillectomy Treatment Outcome Turbinates - surgery |
| title | Respiratory and Auditory Cortical Processing in Children with Obstructive Sleep Apnea Syndrome |
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