Retinoic Acid in the Immune System
On occasion, emerging scientific fields intersect and great discoveries result. In the last decade, the discovery of regulatory T cells (Treg) in immunity has revolutionized our understanding of how the immune system is controlled. Intersecting the rapidly emerging field of Treg function, has been t...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2008-11, Vol.1143 (1), p.170-187 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | Pino-Lagos, Karina Benson, Micah J. Noelle, Randolph J. |
| description | On occasion, emerging scientific fields intersect and great discoveries result. In the last decade, the discovery of regulatory T cells (Treg) in immunity has revolutionized our understanding of how the immune system is controlled. Intersecting the rapidly emerging field of Treg function, has been the discovery that retinoic acid (RA) controls both the homing and differentiation of Treg. Instantly, the wealth and breadth of knowledge of the molecular basis for RA action, its receptors, and how it controls cellular differentiation can and will be exploited to understand its profound effects on Treg. Historically, vitamin A deprivation and repletion and RA agonists have been shown to profoundly affect immunity. Now these findings can be interpreted in light of the revelations that RA controls leukocyte homing and Treg function. |
| doi_str_mv | 10.1196/annals.1443.017 |
| format | Article |
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In the last decade, the discovery of regulatory T cells (Treg) in immunity has revolutionized our understanding of how the immune system is controlled. Intersecting the rapidly emerging field of Treg function, has been the discovery that retinoic acid (RA) controls both the homing and differentiation of Treg. Instantly, the wealth and breadth of knowledge of the molecular basis for RA action, its receptors, and how it controls cellular differentiation can and will be exploited to understand its profound effects on Treg. Historically, vitamin A deprivation and repletion and RA agonists have been shown to profoundly affect immunity. 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| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 2008-11, Vol.1143 (1), p.170-187 |
| issn | 0077-8923 1749-6632 1930-6547 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Cell Differentiation Humans immune system Immune System - physiology retinoic acid Retinol-Binding Proteins - immunology Retinol-Binding Proteins - metabolism Signal Transduction T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism tolerance Tretinoin - metabolism Tretinoin - physiology vitamin A |
| title | Retinoic Acid in the Immune System |
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