Long-Range Chromatin Contacts in Embryonic Stem Cells Reveal a Role for Pluripotency Factors and Polycomb Proteins in Genome Organization

The relationship between 3D organization of the genome and gene-regulatory networks is poorly understood. Here, we examined long-range chromatin interactions genome-wide in mouse embryonic stem cells (ESCs), iPSCs, and fibroblasts and uncovered a pluripotency-specific genome organization that is gra...

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Veröffentlicht in:	Cell stem cell 2013-11, Vol.13 (5), p.602-616
Hauptverfasser:	Denholtz, Matthew, Bonora, Giancarlo, Chronis, Constantinos, Splinter, Erik, de Laat, Wouter, Ernst, Jason, Pellegrini, Matteo, Plath, Kathrin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatin - metabolism Embryonic Stem Cells - metabolism Histones - metabolism In Situ Hybridization, Fluorescence Mice Polycomb-Group Proteins - genetics Polycomb-Group Proteins - metabolism Protein Binding
Online-Zugang:	Volltext
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