Palladium-Catalyzed Asymmetric Construction of Vicinal All-Carbon Quaternary Stereocenters and its Application to the Synthesis of Cyclotryptamine Alkaloids

A twofold Pd‐DAAA Pd‐catalyzed decarboxylative allylic alkylation (see scheme) was used to construct two vicinal all‐carbon quaternary stereocenters (marked in red) in a diastereo‐ and enantioselective fashion. The products of the Pd‐DAAA were further elaborated to complete the formal syntheses of c...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-08, Vol.52 (35), p.9176-9181
Hauptverfasser:	Trost, Barry M., Osipov, Maksim
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaloids Alkaloids - chemical synthesis Alkaloids - chemistry allylic alkylation asymmetric catalysis Carbon - chemistry Catalysis Molecular Structure Organometallic Compounds - chemistry palladium Palladium - chemistry quaternary stereocenters Stereoisomerism Tryptamines - chemical synthesis Tryptamines - chemistry
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