Microenvironment mesenchymal cells protect ovarian cancer cell lines from apoptosis by inhibiting XIAP inactivation

Epithelial ovarian carcinoma is characterized by high frequency of recurrence (70% of patients) and carboplatin resistance acquisition. Carcinoma-associated mesenchymal stem cells (CA-MSC) have been shown to induce ovarian cancer chemoresistance through trogocytosis. Here we examined CA-MSC properti...

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Veröffentlicht in:	Cell death & disease 2013-10, Vol.4 (10), p.e887-e887
Hauptverfasser:	Castells, M, Milhas, D, Gandy, C, Thibault, B, Rafii, A, Delord, J-P, Couderc, B
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/2326 631/67/1517/1709 631/80/82/23 631/80/86 Antibodies Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Blotting, Western Cancer Carboplatin - pharmacology Caspase 3 - metabolism Caspase 7 - metabolism Cell Biology Cell Culture Cell Line Cell Line, Tumor Cisplatin - pharmacology Culture Media, Conditioned - pharmacology Female Humans Immunology Inhibitory Concentration 50 Life Sciences Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Original original-article Ovarian cancer Ovarian Neoplasms - metabolism Pharmaceutical sciences Pharmacology Transfection X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - metabolism
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