TNFR1 signaling kinetics: Spatiotemporal control of three phases of IKK activation by posttranslational modification

TNFα is a pleotropic cytokine that plays a central role in the inflammatory response by activating the NF-κB signaling pathway, and is targeted in a range of chronic inflammatory diseases, underscoring the therapeutic importance of understanding its underlying molecular mechanisms. Although K63-link...

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Veröffentlicht in:	Cellular signalling 2013-08, Vol.25 (8), p.1654-1664
Hauptverfasser:	Workman, Lauren M., Habelhah, Hasem
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism cIAP1 Cytokines Humans I-kappa B Kinase - metabolism Inflammatory response JNK Mitogen-Activated Protein Kinases - metabolism Kinases NF-kappa B - metabolism NF-κB Nuclear Pore Complex Proteins - metabolism Pathways Phases Protein Processing, Post-Translational Reactive Oxygen Species - metabolism Receptors, Tumor Necrosis Factor, Type I - chemistry Receptors, Tumor Necrosis Factor, Type I - metabolism RIP1 RNA-Binding Proteins - metabolism Signal Transduction Strategy Three phase TNF Receptor-Associated Factor 2 - genetics TNF Receptor-Associated Factor 2 - metabolism TNFα TRAF2
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