A comparative study of the effect of diet and soda carbonated drinks on the histology of the cerebellum of adult female albino Wistar rats
Background: Carbonated drinks are widely consumed because of their taste and their ability to refresh and quench thirst. These carbonated drinks also exist in the form of diet drinks, for example Diet Coke® , Pepsi®, extra. Objectives: A comparative effect of the diet and regular soda carbonated dri...
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| Veröffentlicht in: | African health sciences 2013-01, Vol.13 (3), p.541-545 |
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| creator | Eluwa, MA Inyangmme, II Akpantah, AO Ekanem, TB Ekong, MB Asuquo, OR Nwakanma, AA |
| description | Background: Carbonated drinks are widely consumed because of their
taste and their ability to refresh and quench thirst. These carbonated
drinks also exist in the form of diet drinks, for example Diet
Coke® , Pepsi®, extra. Objectives: A comparative effect of
the diet and regular soda carbonated drinks on the histology of the
cerebellum of female albino Wistar rats was investigated. Methods:
Fifteen adult female Wistar rats weighing between 180-200g were divided
into 3 groups; designated as groups A,B and C, and each group consisted
of five rats. Group A was the Control group and received distilled
water, while groups B and C were the experimental groups. Group B was
administered 50 ml of regular soda (RS), and group C was administered
50 ml of diet soda (DS) each per day for 21 days, and the rats were
sacrificed on Day 22, and their cerebellums excised and preserved.
Results: Histological result of the sections of the cerebellum showed
shrunken and degenerated Purkinje cells with hypertrophied dendrites,
especially in the DS group, which was less in the RS group compared to
the control group. Conclusions: These results suggest that diet soda
has adverse effect on the cerebellum of adult female albino Wistar
rats. |
| doi_str_mv | 10.4314/ahs.v13i3.1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3824455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2586790824</sourcerecordid><originalsourceid>FETCH-LOGICAL-b473t-4a8efe2ab211e4cb49e0693b5e947b2e42f579dd7fd8c0e88c33d5eeeda777183</originalsourceid><addsrcrecordid>eNpdkstuFDEQRVsIREJgxR5ZggUSmsHPfmyQooiXFIkNiKVVbVenHbrtwXYPyi_w1XgyyYjMynb51K1y-VbVS0bXUjD5Hsa03jLhxJo9qk5Zw7sVVVQ8Lvu6pau6o-qkepbSNaW8Zh17Wp1wyRXlrTqt_p4TE-YNRMhuiyTlxd6QMJA8IsFhQJN3J-swE_CWpGCBGIh98JDREhud_5VI8LcJo0s5TOHqoGAwYo_TtMy7CNhlymTAGSYkMPXOB_KzpEAkpXx6Xj0ZYEr44m49q358-vj94svq8tvnrxfnl6teNiKvJLQ4IIeeM4bS9LJDWneiV9jJpuco-aCaztpmsK2h2LZGCKsQ0ULTNKwVZ9WHve5m6We0Bn2OMOlNdDPEGx3A6Yc33o36Kmy1aLmUShWBN3cCMfxeMGX9x8XSE9qkuWrrpqOFLNjbI2x2yZRpgMewHKGvj9DrsERfpvCQerenTAwplYqHnhnVOyvoYgV9awXNCv3q_2ce2Pu_L8B6D_QuTM7jgTDRgb4PFsUxMVEaEP8AlyvDFA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2586790824</pqid></control><display><type>article</type><title>A comparative study of the effect of diet and soda carbonated drinks on the histology of the cerebellum of adult female albino Wistar rats</title><source>MEDLINE</source><source>African Journals Online (Open Access)</source><source>Bioline International</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Eluwa, MA ; Inyangmme, II ; Akpantah, AO ; Ekanem, TB ; Ekong, MB ; Asuquo, OR ; Nwakanma, AA</creator><creatorcontrib>Eluwa, MA ; Inyangmme, II ; Akpantah, AO ; Ekanem, TB ; Ekong, MB ; Asuquo, OR ; Nwakanma, AA</creatorcontrib><description>Background: Carbonated drinks are widely consumed because of their
taste and their ability to refresh and quench thirst. These carbonated
drinks also exist in the form of diet drinks, for example Diet
Coke® , Pepsi®, extra. Objectives: A comparative effect of
the diet and regular soda carbonated drinks on the histology of the
cerebellum of female albino Wistar rats was investigated. Methods:
Fifteen adult female Wistar rats weighing between 180-200g were divided
into 3 groups; designated as groups A,B and C, and each group consisted
of five rats. Group A was the Control group and received distilled
water, while groups B and C were the experimental groups. Group B was
administered 50 ml of regular soda (RS), and group C was administered
50 ml of diet soda (DS) each per day for 21 days, and the rats were
sacrificed on Day 22, and their cerebellums excised and preserved.
Results: Histological result of the sections of the cerebellum showed
shrunken and degenerated Purkinje cells with hypertrophied dendrites,
especially in the DS group, which was less in the RS group compared to
the control group. Conclusions: These results suggest that diet soda
has adverse effect on the cerebellum of adult female albino Wistar
rats.</description><identifier>ISSN: 1680-6905</identifier><identifier>EISSN: 1729-0503</identifier><identifier>EISSN: 1680-6905</identifier><identifier>DOI: 10.4314/ahs.v13i3.1</identifier><identifier>PMID: 24250285</identifier><language>eng</language><publisher>Uganda: Makerere University Medical School</publisher><subject>Animals ; Beverages ; Brain ; Carbonated Beverages - adverse effects ; Carbonated drink, Diet soda, regular soda, Cerebellum, Wistar rats ; Cerebellum - anatomy & histology ; Cerebellum - drug effects ; Diet, Carbohydrate-Restricted ; Dose-Response Relationship, Drug ; Experiments ; Female ; Health and Medicine ; Histological Techniques ; Original ; Rats ; Rats, Wistar</subject><ispartof>African health sciences, 2013-01, Vol.13 (3), p.541-545</ispartof><rights>African Health Sciences</rights><rights>Copyright © Makerere Medical School, Uganda 2013 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b473t-4a8efe2ab211e4cb49e0693b5e947b2e42f579dd7fd8c0e88c33d5eeeda777183</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824455/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824455/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798,79431</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24250285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eluwa, MA</creatorcontrib><creatorcontrib>Inyangmme, II</creatorcontrib><creatorcontrib>Akpantah, AO</creatorcontrib><creatorcontrib>Ekanem, TB</creatorcontrib><creatorcontrib>Ekong, MB</creatorcontrib><creatorcontrib>Asuquo, OR</creatorcontrib><creatorcontrib>Nwakanma, AA</creatorcontrib><title>A comparative study of the effect of diet and soda carbonated drinks on the histology of the cerebellum of adult female albino Wistar rats</title><title>African health sciences</title><addtitle>Afr Health Sci</addtitle><description>Background: Carbonated drinks are widely consumed because of their
taste and their ability to refresh and quench thirst. These carbonated
drinks also exist in the form of diet drinks, for example Diet
Coke® , Pepsi®, extra. Objectives: A comparative effect of
the diet and regular soda carbonated drinks on the histology of the
cerebellum of female albino Wistar rats was investigated. Methods:
Fifteen adult female Wistar rats weighing between 180-200g were divided
into 3 groups; designated as groups A,B and C, and each group consisted
of five rats. Group A was the Control group and received distilled
water, while groups B and C were the experimental groups. Group B was
administered 50 ml of regular soda (RS), and group C was administered
50 ml of diet soda (DS) each per day for 21 days, and the rats were
sacrificed on Day 22, and their cerebellums excised and preserved.
Results: Histological result of the sections of the cerebellum showed
shrunken and degenerated Purkinje cells with hypertrophied dendrites,
especially in the DS group, which was less in the RS group compared to
the control group. Conclusions: These results suggest that diet soda
has adverse effect on the cerebellum of adult female albino Wistar
rats.</description><subject>Animals</subject><subject>Beverages</subject><subject>Brain</subject><subject>Carbonated Beverages - adverse effects</subject><subject>Carbonated drink, Diet soda, regular soda, Cerebellum, Wistar rats</subject><subject>Cerebellum - anatomy & histology</subject><subject>Cerebellum - drug effects</subject><subject>Diet, Carbohydrate-Restricted</subject><subject>Dose-Response Relationship, Drug</subject><subject>Experiments</subject><subject>Female</subject><subject>Health and Medicine</subject><subject>Histological Techniques</subject><subject>Original</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>1680-6905</issn><issn>1729-0503</issn><issn>1680-6905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><recordid>eNpdkstuFDEQRVsIREJgxR5ZggUSmsHPfmyQooiXFIkNiKVVbVenHbrtwXYPyi_w1XgyyYjMynb51K1y-VbVS0bXUjD5Hsa03jLhxJo9qk5Zw7sVVVQ8Lvu6pau6o-qkepbSNaW8Zh17Wp1wyRXlrTqt_p4TE-YNRMhuiyTlxd6QMJA8IsFhQJN3J-swE_CWpGCBGIh98JDREhud_5VI8LcJo0s5TOHqoGAwYo_TtMy7CNhlymTAGSYkMPXOB_KzpEAkpXx6Xj0ZYEr44m49q358-vj94svq8tvnrxfnl6teNiKvJLQ4IIeeM4bS9LJDWneiV9jJpuco-aCaztpmsK2h2LZGCKsQ0ULTNKwVZ9WHve5m6We0Bn2OMOlNdDPEGx3A6Yc33o36Kmy1aLmUShWBN3cCMfxeMGX9x8XSE9qkuWrrpqOFLNjbI2x2yZRpgMewHKGvj9DrsERfpvCQerenTAwplYqHnhnVOyvoYgV9awXNCv3q_2ce2Pu_L8B6D_QuTM7jgTDRgb4PFsUxMVEaEP8AlyvDFA</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Eluwa, MA</creator><creator>Inyangmme, II</creator><creator>Akpantah, AO</creator><creator>Ekanem, TB</creator><creator>Ekong, MB</creator><creator>Asuquo, OR</creator><creator>Nwakanma, AA</creator><general>Makerere University Medical School</general><general>Makerere Medical School</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>A comparative study of the effect of diet and soda carbonated drinks on the histology of the cerebellum of adult female albino Wistar rats</title><author>Eluwa, MA ; Inyangmme, II ; Akpantah, AO ; Ekanem, TB ; Ekong, MB ; Asuquo, OR ; Nwakanma, AA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b473t-4a8efe2ab211e4cb49e0693b5e947b2e42f579dd7fd8c0e88c33d5eeeda777183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Beverages</topic><topic>Brain</topic><topic>Carbonated Beverages - adverse effects</topic><topic>Carbonated drink, Diet soda, regular soda, Cerebellum, Wistar rats</topic><topic>Cerebellum - anatomy & histology</topic><topic>Cerebellum - drug effects</topic><topic>Diet, Carbohydrate-Restricted</topic><topic>Dose-Response Relationship, Drug</topic><topic>Experiments</topic><topic>Female</topic><topic>Health and Medicine</topic><topic>Histological Techniques</topic><topic>Original</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eluwa, MA</creatorcontrib><creatorcontrib>Inyangmme, II</creatorcontrib><creatorcontrib>Akpantah, AO</creatorcontrib><creatorcontrib>Ekanem, TB</creatorcontrib><creatorcontrib>Ekong, MB</creatorcontrib><creatorcontrib>Asuquo, OR</creatorcontrib><creatorcontrib>Nwakanma, AA</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African health sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eluwa, MA</au><au>Inyangmme, II</au><au>Akpantah, AO</au><au>Ekanem, TB</au><au>Ekong, MB</au><au>Asuquo, OR</au><au>Nwakanma, AA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative study of the effect of diet and soda carbonated drinks on the histology of the cerebellum of adult female albino Wistar rats</atitle><jtitle>African health sciences</jtitle><addtitle>Afr Health Sci</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>13</volume><issue>3</issue><spage>541</spage><epage>545</epage><pages>541-545</pages><issn>1680-6905</issn><eissn>1729-0503</eissn><eissn>1680-6905</eissn><abstract>Background: Carbonated drinks are widely consumed because of their
taste and their ability to refresh and quench thirst. These carbonated
drinks also exist in the form of diet drinks, for example Diet
Coke® , Pepsi®, extra. Objectives: A comparative effect of
the diet and regular soda carbonated drinks on the histology of the
cerebellum of female albino Wistar rats was investigated. Methods:
Fifteen adult female Wistar rats weighing between 180-200g were divided
into 3 groups; designated as groups A,B and C, and each group consisted
of five rats. Group A was the Control group and received distilled
water, while groups B and C were the experimental groups. Group B was
administered 50 ml of regular soda (RS), and group C was administered
50 ml of diet soda (DS) each per day for 21 days, and the rats were
sacrificed on Day 22, and their cerebellums excised and preserved.
Results: Histological result of the sections of the cerebellum showed
shrunken and degenerated Purkinje cells with hypertrophied dendrites,
especially in the DS group, which was less in the RS group compared to
the control group. Conclusions: These results suggest that diet soda
has adverse effect on the cerebellum of adult female albino Wistar
rats.</abstract><cop>Uganda</cop><pub>Makerere University Medical School</pub><pmid>24250285</pmid><doi>10.4314/ahs.v13i3.1</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1680-6905 |
| ispartof | African health sciences, 2013-01, Vol.13 (3), p.541-545 |
| issn | 1680-6905 1729-0503 1680-6905 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3824455 |
| source | MEDLINE; African Journals Online (Open Access); Bioline International; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Beverages Brain Carbonated Beverages - adverse effects Carbonated drink, Diet soda, regular soda, Cerebellum, Wistar rats Cerebellum - anatomy & histology Cerebellum - drug effects Diet, Carbohydrate-Restricted Dose-Response Relationship, Drug Experiments Female Health and Medicine Histological Techniques Original Rats Rats, Wistar |
| title | A comparative study of the effect of diet and soda carbonated drinks on the histology of the cerebellum of adult female albino Wistar rats |
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