Deoxynivalenol affects the composition of the basement membrane proteins and influences en route the migration of CD16⁺ cells into the intestinal epithelium
The numerous pores in the basement membrane (BM) of the intestinal villi are essential for the communication of enterocytes with cells in the lamina propria, an important mechanism for the induction of intestinal immune responses. The intestinal epithelial barrier is affected by the mycotoxin deoxyn...
Gespeichert in:
Veröffentlicht in: | Mycotoxin research 2013-11, Vol.29 (4), p.245-254 |
---|---|
Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 254 |
---|---|
container_issue | 4 |
container_start_page | 245 |
container_title | Mycotoxin research |
container_volume | 29 |
creator | Nossol, Constanze Diesing, A. K Kahlert, S Kersten, S Kluess, J Ponsuksili, S Hartig, R Wimmers, K Dänicke, S Rothkötter, H. J |
description | The numerous pores in the basement membrane (BM) of the intestinal villi are essential for the communication of enterocytes with cells in the lamina propria, an important mechanism for the induction of intestinal immune responses. The intestinal epithelial barrier is affected by the mycotoxin deoxynivalenol (DON) from both the apical (luminal) and basolateral (serosal) side. The pig is the most susceptible species to the anorectic and immune-modulating effects of DON, which is most prevalent in crops. We analysed in pigs the effect of DON-contaminated feed on the composition and perforation of the BM and the presence of CD16⁺ cells or their dendrites in the epithelium. In addition to in vivo experiments, in vitro studies were carried out. Using microarray analyses, the effects of DON on IPEC-J2 cells were studied with the focus on the BM. Our in vivo results showed in the control pigs: (1) a significant increased pore number (p ≤ 0.001) in the jejunum in comparison to ileum, (2) no difference in the pore size, and (3) comparable frequency of intraepithelial CD16⁺ cells/dendrites in the jejunum and ileum. There was a marked trend that DON feeding increases: (1) the pore number in jejunum, and (2) the number of CD16⁺ cells/dendrites in the epithelium (Tukey–Kramer; p = 0.055 and p = 0.067, respectively). The in vivo results were extended with microarray analyses of epithelial cell (IPEC-J2 cells). The down-regulation of genes like syndecan, fibulin 6 and BM-40 was observed. These proteins are important factors in the BM composition and in formation of pores. Our results provide evidence that already low basolateral concentrations of DON (50 ng/mL) influence the production of the BM protein laminin by epithelial cells. Thus, DON affects the composition of the BM. |
doi_str_mv | 10.1007/s12550-013-0177-8 |
format | Article |
fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3824239</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>23949948</sourcerecordid><originalsourceid>FETCH-LOGICAL-c496t-54fb9ff48ae961b8d642016feed570ed1a397e0721977c46d2dc1c77332ef4643</originalsourceid><addsrcrecordid>eNp9UUtuFDEUbCEQGQIHYAPesGzwb2z3BglN-EmRWEDWltv9PHHktlt2T5QsuUgOkuNwEjzTSYANC8vWe1X1nqua5iXBbwnG8l0hdL3GLSasHilb9ahZESVkSwSjj5tVLapWKqWOmmelXGAsGBfqaXNEWce7jqtVc3MC6eo6-ksTIKaAjHNg54Lmc0A2jVMqfvYpouQOpd4UGCHOaISxzyYCmnKawceCTByQjy7sIFooCCLKaTfDgTb6bTb3OpsTIn79vEUWQiiVMqcDpj6gzD6agGDytRL8bnzePHEmFHhxdx83Z58-_th8aU-_ff66-XDaWt6JuV1z13fOcWWgE6RXg-AUE-EAhrXEMBDDOglYUtJJabkY6GCJlZIxCo4Lzo6b94vutOtHGGz9YjZBT9mPJl_rZLz-txP9ud6mS80U5dXNKkAWAZtTKRncA5dgvQ9LL2HpGpbeh6VV5bz6e-gD4z6dCnhzBzDFmuCq4daXPziphOJ0vz1dcKW24hayvki7XJ0s_53-eiE5k7TZ5ip89r26xjHGqhMMs9-FYrvT</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Deoxynivalenol affects the composition of the basement membrane proteins and influences en route the migration of CD16⁺ cells into the intestinal epithelium</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Nossol, Constanze ; Diesing, A. K ; Kahlert, S ; Kersten, S ; Kluess, J ; Ponsuksili, S ; Hartig, R ; Wimmers, K ; Dänicke, S ; Rothkötter, H. J</creator><creatorcontrib>Nossol, Constanze ; Diesing, A. K ; Kahlert, S ; Kersten, S ; Kluess, J ; Ponsuksili, S ; Hartig, R ; Wimmers, K ; Dänicke, S ; Rothkötter, H. J</creatorcontrib><description>The numerous pores in the basement membrane (BM) of the intestinal villi are essential for the communication of enterocytes with cells in the lamina propria, an important mechanism for the induction of intestinal immune responses. The intestinal epithelial barrier is affected by the mycotoxin deoxynivalenol (DON) from both the apical (luminal) and basolateral (serosal) side. The pig is the most susceptible species to the anorectic and immune-modulating effects of DON, which is most prevalent in crops. We analysed in pigs the effect of DON-contaminated feed on the composition and perforation of the BM and the presence of CD16⁺ cells or their dendrites in the epithelium. In addition to in vivo experiments, in vitro studies were carried out. Using microarray analyses, the effects of DON on IPEC-J2 cells were studied with the focus on the BM. Our in vivo results showed in the control pigs: (1) a significant increased pore number (p ≤ 0.001) in the jejunum in comparison to ileum, (2) no difference in the pore size, and (3) comparable frequency of intraepithelial CD16⁺ cells/dendrites in the jejunum and ileum. There was a marked trend that DON feeding increases: (1) the pore number in jejunum, and (2) the number of CD16⁺ cells/dendrites in the epithelium (Tukey–Kramer; p = 0.055 and p = 0.067, respectively). The in vivo results were extended with microarray analyses of epithelial cell (IPEC-J2 cells). The down-regulation of genes like syndecan, fibulin 6 and BM-40 was observed. These proteins are important factors in the BM composition and in formation of pores. Our results provide evidence that already low basolateral concentrations of DON (50 ng/mL) influence the production of the BM protein laminin by epithelial cells. Thus, DON affects the composition of the BM.</description><identifier>ISSN: 0178-7888</identifier><identifier>EISSN: 1867-1632</identifier><identifier>DOI: 10.1007/s12550-013-0177-8</identifier><identifier>PMID: 23949948</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animal Feed - toxicity ; Animals ; basement membrane ; Basement Membrane - cytology ; Basement Membrane - immunology ; Basement Membrane - ultrastructure ; Biological and medical sciences ; Biomedical and Life Sciences ; Blotting, Western ; Cell Line ; Cell Movement - immunology ; Chemistry/Food Science ; crops ; dendrites ; deoxynivalenol ; enterocytes ; Epithelial Cells ; Food Contamination ; Fundamental and applied biological sciences. Psychology ; gene expression regulation ; genes ; ileum ; immune response ; in vitro studies ; in vivo studies ; Intestinal Mucosa - cytology ; Intestinal Mucosa - immunology ; Intestinal Mucosa - ultrastructure ; jejunum ; laminin ; Least-Squares Analysis ; Life Sciences ; Male ; Medical Microbiology ; Medicine/Public Health ; Membrane Proteins - genetics ; Membrane Proteins - immunology ; microarray technology ; Microbiology ; Microscopy, Confocal - veterinary ; Microscopy, Fluorescence - veterinary ; Mycology ; Oligonucleotide Array Sequence Analysis - veterinary ; Original Paper ; Pathogenicity, host-agent relations, miscellaneous strains, epidemiology ; RNA - chemistry ; RNA - genetics ; swine ; Swine - immunology ; Trichothecenes - pharmacology ; villi</subject><ispartof>Mycotoxin research, 2013-11, Vol.29 (4), p.245-254</ispartof><rights>The Author(s) 2013</rights><rights>2015 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-54fb9ff48ae961b8d642016feed570ed1a397e0721977c46d2dc1c77332ef4643</citedby><cites>FETCH-LOGICAL-c496t-54fb9ff48ae961b8d642016feed570ed1a397e0721977c46d2dc1c77332ef4643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12550-013-0177-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12550-013-0177-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27868424$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23949948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nossol, Constanze</creatorcontrib><creatorcontrib>Diesing, A. K</creatorcontrib><creatorcontrib>Kahlert, S</creatorcontrib><creatorcontrib>Kersten, S</creatorcontrib><creatorcontrib>Kluess, J</creatorcontrib><creatorcontrib>Ponsuksili, S</creatorcontrib><creatorcontrib>Hartig, R</creatorcontrib><creatorcontrib>Wimmers, K</creatorcontrib><creatorcontrib>Dänicke, S</creatorcontrib><creatorcontrib>Rothkötter, H. J</creatorcontrib><title>Deoxynivalenol affects the composition of the basement membrane proteins and influences en route the migration of CD16⁺ cells into the intestinal epithelium</title><title>Mycotoxin research</title><addtitle>Mycotoxin Res</addtitle><addtitle>Mycotoxin Res</addtitle><description>The numerous pores in the basement membrane (BM) of the intestinal villi are essential for the communication of enterocytes with cells in the lamina propria, an important mechanism for the induction of intestinal immune responses. The intestinal epithelial barrier is affected by the mycotoxin deoxynivalenol (DON) from both the apical (luminal) and basolateral (serosal) side. The pig is the most susceptible species to the anorectic and immune-modulating effects of DON, which is most prevalent in crops. We analysed in pigs the effect of DON-contaminated feed on the composition and perforation of the BM and the presence of CD16⁺ cells or their dendrites in the epithelium. In addition to in vivo experiments, in vitro studies were carried out. Using microarray analyses, the effects of DON on IPEC-J2 cells were studied with the focus on the BM. Our in vivo results showed in the control pigs: (1) a significant increased pore number (p ≤ 0.001) in the jejunum in comparison to ileum, (2) no difference in the pore size, and (3) comparable frequency of intraepithelial CD16⁺ cells/dendrites in the jejunum and ileum. There was a marked trend that DON feeding increases: (1) the pore number in jejunum, and (2) the number of CD16⁺ cells/dendrites in the epithelium (Tukey–Kramer; p = 0.055 and p = 0.067, respectively). The in vivo results were extended with microarray analyses of epithelial cell (IPEC-J2 cells). The down-regulation of genes like syndecan, fibulin 6 and BM-40 was observed. These proteins are important factors in the BM composition and in formation of pores. Our results provide evidence that already low basolateral concentrations of DON (50 ng/mL) influence the production of the BM protein laminin by epithelial cells. Thus, DON affects the composition of the BM.</description><subject>Animal Feed - toxicity</subject><subject>Animals</subject><subject>basement membrane</subject><subject>Basement Membrane - cytology</subject><subject>Basement Membrane - immunology</subject><subject>Basement Membrane - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Blotting, Western</subject><subject>Cell Line</subject><subject>Cell Movement - immunology</subject><subject>Chemistry/Food Science</subject><subject>crops</subject><subject>dendrites</subject><subject>deoxynivalenol</subject><subject>enterocytes</subject><subject>Epithelial Cells</subject><subject>Food Contamination</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gene expression regulation</subject><subject>genes</subject><subject>ileum</subject><subject>immune response</subject><subject>in vitro studies</subject><subject>in vivo studies</subject><subject>Intestinal Mucosa - cytology</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestinal Mucosa - ultrastructure</subject><subject>jejunum</subject><subject>laminin</subject><subject>Least-Squares Analysis</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Medicine/Public Health</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - immunology</subject><subject>microarray technology</subject><subject>Microbiology</subject><subject>Microscopy, Confocal - veterinary</subject><subject>Microscopy, Fluorescence - veterinary</subject><subject>Mycology</subject><subject>Oligonucleotide Array Sequence Analysis - veterinary</subject><subject>Original Paper</subject><subject>Pathogenicity, host-agent relations, miscellaneous strains, epidemiology</subject><subject>RNA - chemistry</subject><subject>RNA - genetics</subject><subject>swine</subject><subject>Swine - immunology</subject><subject>Trichothecenes - pharmacology</subject><subject>villi</subject><issn>0178-7888</issn><issn>1867-1632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9UUtuFDEUbCEQGQIHYAPesGzwb2z3BglN-EmRWEDWltv9PHHktlt2T5QsuUgOkuNwEjzTSYANC8vWe1X1nqua5iXBbwnG8l0hdL3GLSasHilb9ahZESVkSwSjj5tVLapWKqWOmmelXGAsGBfqaXNEWce7jqtVc3MC6eo6-ksTIKaAjHNg54Lmc0A2jVMqfvYpouQOpd4UGCHOaISxzyYCmnKawceCTByQjy7sIFooCCLKaTfDgTb6bTb3OpsTIn79vEUWQiiVMqcDpj6gzD6agGDytRL8bnzePHEmFHhxdx83Z58-_th8aU-_ff66-XDaWt6JuV1z13fOcWWgE6RXg-AUE-EAhrXEMBDDOglYUtJJabkY6GCJlZIxCo4Lzo6b94vutOtHGGz9YjZBT9mPJl_rZLz-txP9ud6mS80U5dXNKkAWAZtTKRncA5dgvQ9LL2HpGpbeh6VV5bz6e-gD4z6dCnhzBzDFmuCq4daXPziphOJ0vz1dcKW24hayvki7XJ0s_53-eiE5k7TZ5ip89r26xjHGqhMMs9-FYrvT</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Nossol, Constanze</creator><creator>Diesing, A. K</creator><creator>Kahlert, S</creator><creator>Kersten, S</creator><creator>Kluess, J</creator><creator>Ponsuksili, S</creator><creator>Hartig, R</creator><creator>Wimmers, K</creator><creator>Dänicke, S</creator><creator>Rothkötter, H. J</creator><general>Springer-Verlag</general><general>Springer Berlin Heidelberg</general><general>Springer</general><scope>FBQ</scope><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20131101</creationdate><title>Deoxynivalenol affects the composition of the basement membrane proteins and influences en route the migration of CD16⁺ cells into the intestinal epithelium</title><author>Nossol, Constanze ; Diesing, A. K ; Kahlert, S ; Kersten, S ; Kluess, J ; Ponsuksili, S ; Hartig, R ; Wimmers, K ; Dänicke, S ; Rothkötter, H. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-54fb9ff48ae961b8d642016feed570ed1a397e0721977c46d2dc1c77332ef4643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animal Feed - toxicity</topic><topic>Animals</topic><topic>basement membrane</topic><topic>Basement Membrane - cytology</topic><topic>Basement Membrane - immunology</topic><topic>Basement Membrane - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Blotting, Western</topic><topic>Cell Line</topic><topic>Cell Movement - immunology</topic><topic>Chemistry/Food Science</topic><topic>crops</topic><topic>dendrites</topic><topic>deoxynivalenol</topic><topic>enterocytes</topic><topic>Epithelial Cells</topic><topic>Food Contamination</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gene expression regulation</topic><topic>genes</topic><topic>ileum</topic><topic>immune response</topic><topic>in vitro studies</topic><topic>in vivo studies</topic><topic>Intestinal Mucosa - cytology</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intestinal Mucosa - ultrastructure</topic><topic>jejunum</topic><topic>laminin</topic><topic>Least-Squares Analysis</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Medicine/Public Health</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - immunology</topic><topic>microarray technology</topic><topic>Microbiology</topic><topic>Microscopy, Confocal - veterinary</topic><topic>Microscopy, Fluorescence - veterinary</topic><topic>Mycology</topic><topic>Oligonucleotide Array Sequence Analysis - veterinary</topic><topic>Original Paper</topic><topic>Pathogenicity, host-agent relations, miscellaneous strains, epidemiology</topic><topic>RNA - chemistry</topic><topic>RNA - genetics</topic><topic>swine</topic><topic>Swine - immunology</topic><topic>Trichothecenes - pharmacology</topic><topic>villi</topic><toplevel>online_resources</toplevel><creatorcontrib>Nossol, Constanze</creatorcontrib><creatorcontrib>Diesing, A. K</creatorcontrib><creatorcontrib>Kahlert, S</creatorcontrib><creatorcontrib>Kersten, S</creatorcontrib><creatorcontrib>Kluess, J</creatorcontrib><creatorcontrib>Ponsuksili, S</creatorcontrib><creatorcontrib>Hartig, R</creatorcontrib><creatorcontrib>Wimmers, K</creatorcontrib><creatorcontrib>Dänicke, S</creatorcontrib><creatorcontrib>Rothkötter, H. J</creatorcontrib><collection>AGRIS</collection><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mycotoxin research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nossol, Constanze</au><au>Diesing, A. K</au><au>Kahlert, S</au><au>Kersten, S</au><au>Kluess, J</au><au>Ponsuksili, S</au><au>Hartig, R</au><au>Wimmers, K</au><au>Dänicke, S</au><au>Rothkötter, H. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deoxynivalenol affects the composition of the basement membrane proteins and influences en route the migration of CD16⁺ cells into the intestinal epithelium</atitle><jtitle>Mycotoxin research</jtitle><stitle>Mycotoxin Res</stitle><addtitle>Mycotoxin Res</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>29</volume><issue>4</issue><spage>245</spage><epage>254</epage><pages>245-254</pages><issn>0178-7888</issn><eissn>1867-1632</eissn><abstract>The numerous pores in the basement membrane (BM) of the intestinal villi are essential for the communication of enterocytes with cells in the lamina propria, an important mechanism for the induction of intestinal immune responses. The intestinal epithelial barrier is affected by the mycotoxin deoxynivalenol (DON) from both the apical (luminal) and basolateral (serosal) side. The pig is the most susceptible species to the anorectic and immune-modulating effects of DON, which is most prevalent in crops. We analysed in pigs the effect of DON-contaminated feed on the composition and perforation of the BM and the presence of CD16⁺ cells or their dendrites in the epithelium. In addition to in vivo experiments, in vitro studies were carried out. Using microarray analyses, the effects of DON on IPEC-J2 cells were studied with the focus on the BM. Our in vivo results showed in the control pigs: (1) a significant increased pore number (p ≤ 0.001) in the jejunum in comparison to ileum, (2) no difference in the pore size, and (3) comparable frequency of intraepithelial CD16⁺ cells/dendrites in the jejunum and ileum. There was a marked trend that DON feeding increases: (1) the pore number in jejunum, and (2) the number of CD16⁺ cells/dendrites in the epithelium (Tukey–Kramer; p = 0.055 and p = 0.067, respectively). The in vivo results were extended with microarray analyses of epithelial cell (IPEC-J2 cells). The down-regulation of genes like syndecan, fibulin 6 and BM-40 was observed. These proteins are important factors in the BM composition and in formation of pores. Our results provide evidence that already low basolateral concentrations of DON (50 ng/mL) influence the production of the BM protein laminin by epithelial cells. Thus, DON affects the composition of the BM.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23949948</pmid><doi>10.1007/s12550-013-0177-8</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0178-7888 |
ispartof | Mycotoxin research, 2013-11, Vol.29 (4), p.245-254 |
issn | 0178-7888 1867-1632 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3824239 |
source | MEDLINE; SpringerNature Journals |
subjects | Animal Feed - toxicity Animals basement membrane Basement Membrane - cytology Basement Membrane - immunology Basement Membrane - ultrastructure Biological and medical sciences Biomedical and Life Sciences Blotting, Western Cell Line Cell Movement - immunology Chemistry/Food Science crops dendrites deoxynivalenol enterocytes Epithelial Cells Food Contamination Fundamental and applied biological sciences. Psychology gene expression regulation genes ileum immune response in vitro studies in vivo studies Intestinal Mucosa - cytology Intestinal Mucosa - immunology Intestinal Mucosa - ultrastructure jejunum laminin Least-Squares Analysis Life Sciences Male Medical Microbiology Medicine/Public Health Membrane Proteins - genetics Membrane Proteins - immunology microarray technology Microbiology Microscopy, Confocal - veterinary Microscopy, Fluorescence - veterinary Mycology Oligonucleotide Array Sequence Analysis - veterinary Original Paper Pathogenicity, host-agent relations, miscellaneous strains, epidemiology RNA - chemistry RNA - genetics swine Swine - immunology Trichothecenes - pharmacology villi |
title | Deoxynivalenol affects the composition of the basement membrane proteins and influences en route the migration of CD16⁺ cells into the intestinal epithelium |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T03%3A42%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Deoxynivalenol%20affects%20the%20composition%20of%20the%20basement%20membrane%20proteins%20and%20influences%20en%20route%20the%20migration%20of%20CD16%E2%81%BA%20cells%20into%20the%20intestinal%20epithelium&rft.jtitle=Mycotoxin%20research&rft.au=Nossol,%20Constanze&rft.date=2013-11-01&rft.volume=29&rft.issue=4&rft.spage=245&rft.epage=254&rft.pages=245-254&rft.issn=0178-7888&rft.eissn=1867-1632&rft_id=info:doi/10.1007/s12550-013-0177-8&rft_dat=%3Cpubmed_cross%3E23949948%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/23949948&rfr_iscdi=true |