A statistical strategy to identify recombinant viral ribonucleoprotein of avian, human, and swine influenza A viruses with elevated polymerase activity

Objectives Reassortment of influenza A viruses can give rise to viral ribonucleoproteins (vRNPs) with elevated polymerase activity and the previous three pandemic influenza viruses contained reassorted vRNPs of different origins. These suggest that reassorted vRNP may be one of the factors leading t...

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Veröffentlicht in:	Influenza and other respiratory viruses 2013-11, Vol.7 (6), p.969-978
Hauptverfasser:	Chin, Alex W. H., Greenbaum, Benjamin D., Li, Olive T. W., Webby, Richard J., Poon, Leo L. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Artificial Gene Fusion Cell Line Fractional factorial design Genes, Reporter Humans Influenza A Influenza A virus - enzymology influenza virus Luciferases - genetics Luciferases - metabolism Original Part 1 polymerase reassortment Recombinant Proteins - genetics Recombinant Proteins - metabolism Reverse Genetics Ribonucleoproteins - genetics Ribonucleoproteins - metabolism RNA-Dependent RNA Polymerase - genetics RNA-Dependent RNA Polymerase - metabolism
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