Atorvastatin activates heme oxygenase‐1 at the stress response elements

Statins are known to inhibit growth of a number of cancer cells, but their mechanism of action is not well established. In this study, human prostate adenocarcinoma PC‐3 and breast adenocarcinoma MCF‐7 cell lines were used as models to investigate the mechanism of action of atorvastatin, one of the...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2012-02, Vol.16 (2), p.394-400
Hauptverfasser:	Kwok, Simon C.M., Samuel, Solomon P., Handal, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma antioxidant response element Antioxidants Apoptosis Apoptosis - drug effects Atorvastatin Atorvastatin Calcium Binding sites Breast cancer Breast Neoplasms Cell culture Cell cycle Cell death Cell growth Cell Line, Tumor Cellular stress response Female Heme oxygenase (decyclizing) Heme Oxygenase-1 - metabolism heme oxygenase‐1 Heptanoic Acids - pharmacology Humans Male Original Oxidative stress Oxidative Stress - drug effects Plasmids Polyisoprenyl Phosphates - pharmacology Promoter Regions, Genetic Prostate Prostate cancer Prostatic Neoplasms Pyrroles - pharmacology Regulatory sequences Signal Transduction - drug effects statin Statins Transcription factors Transcriptional Activation Tumor cell lines Up-regulation Up-Regulation - drug effects
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