Cardiomyogenic differentiation‐independent improvement of cardiac function by human cardiomyocyte progenitor cell injection in ischaemic mouse hearts

We previously showed that human cardiomyocyte progenitor cells (hCMPCs) injected after myocardial infarction (MI) had differentiated into cardiomyocytes in vivo 3 months after MI. Here, we investigated the short‐term (2 weeks) effects of hCMPCs on the infarcted mouse myocardium. MI was induced in im...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2012-07, Vol.16 (7), p.1508-1521
Hauptverfasser:	den Haan, Melina C., Grauss, Robert W., Smits, Anke M., Winter, Elizabeth M., van Tuyn, John, Pijnappels, Daniël A., Steendijk, Paul, Gittenberger‐De Groot, Adriana C., van der Laarse, Arnoud, Fibbe, Willem E., de Vries, Antoine A. F., Schalij, Martin J., Doevendans, Pieter A., Goumans, Marie‐José, Atsma, Douwe E.
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Antibodies Antigens Cardiac function cardiomyocyte progenitor cell Cardiomyocytes Cell Differentiation Cells, Cultured Collagen Experiments Green fluorescent protein Green Fluorescent Proteins - metabolism Heart attacks Heart rate Homeostasis Humans Ischemia Ischemia - pathology Ischemia - therapy Laboratory animals Magnetic Resonance Imaging Male Mice Mice, Inbred NOD Mice, SCID Myoblasts - cytology Myoblasts - transplantation Myocardial infarction Myocardial Infarction - pathology Myocardial Infarction - therapy Myocardium Myocytes, Cardiac - cytology Original Ostomy paracrine factors Paracrine signalling Progenitor cells remodelling Software Stem cell transplantation Stem cells Ventricle Ventricular Function, Left Ventricular Remodeling
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