Grp94 acts as a mediator of curcumin‐induced antioxidant defence in myogenic cells

Curcumin is a non‐toxic polyphenol with pleiotropic activities and limited bioavailability. We investigated whether a brief exposure to low doses of curcumin would induce in the myogenic C2C12 cell line an endoplasmic reticulum (ER) stress response and protect against oxidative stress. A 3‐hr curcum...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2010-04, Vol.14 (4), p.970-981
Hauptverfasser:	Pizzo, Paola, Scapin, Cristina, Vitadello, Maurizio, Florean, Cristina, Gorza, Luisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Antisense DNA Apoptosis Bioavailability C2C12 Calcium Calcium (intracellular) Calcium homeostasis Calreticulin Caspase-12 Cell activation Cell death Cellular biology Cellular stress response Cloning Curcumin Endoplasmic reticulum Fura-2 Gene expression Glycerol Grp94 GRP94 protein Homeostasis Hydrogen peroxide Monoclonal antibodies NF-κB protein NF‐κB Oxidation Oxidative stress Polyclonal antibodies Polyphenols Protein transport Proteins reactive oxygen species Transfection unfolded protein response
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