Chromosomal variability of human mesenchymal stem cells cultured under hypoxic conditions

Bone marrow derived human mesenchymal stem cells (hMSCs) have attracted great interest from both bench and clinical researchers because of their pluripotency and ease of expansion ex vivo. However, these cells do finally reach a senescent stage and lose their multipotent potential. Proliferation of...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2012-01, Vol.16 (1), p.72-82
Hauptverfasser:	Ueyama, Hanae, Horibe, Tomohisa, Hinotsu, Shiro, Tanaka, Tomoaki, Inoue, Takeomi, Urushihara, Hisashi, Kitagawa, Akira, Kawakami, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aneuploidy Antibiotics Bone marrow Bone Marrow Cells - cytology bone marrow derived mesenchymal stem cells Cell culture Cell Culture Techniques Cell Differentiation - physiology Cell Proliferation Cells, Cultured Child chromosomal aberration Chromosome Aberrations Chromosomes Chromosomes - genetics Chromosomes - metabolism Fibroblasts Genomic instability Good Manufacturing Practice Humans Hypoxia Hypoxia - metabolism karyotype Karyotyping Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology Middle Aged Mutation Original Oxygen - metabolism Pluripotency Propagation regenerative medicine Regression analysis Senescence Stem cells Therapeutic applications Tissue engineering
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