A new oncolytic adenoviral vector carrying dual tumour suppressor genes shows potent anti‐tumour effect

Cancer Targeting Gene‐Viro‐Therapy (CTGVT) is a promising cancer therapeutical strategy that strengthens the anti‐tumour effect of oncolytic virus by expressing inserted foreign anti‐tumour genes. In this work, we constructed a novel adenoviral vector controlled by the tumour‐specific survivin promo...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2012-06, Vol.16 (6), p.1298-1309
Hauptverfasser:	Liu, Xin‐Ran, Cai, Ying, Cao, Xin, Wei, Rui‐Cheng, Li, Hui‐Ling, Zhou, Xiu‐Mei, Zhang, Kang‐Jian, Wu, Shuai, Qian, Qi‐Jun, Cheng, Biao, Huang, Kun, Liu, Xin‐Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviruses Animals Apoptosis Bladder cancer cancer gene therapy Cell Line, Tumor DNA-directed RNA polymerase Female Gene Deletion Gene Expression Regulation Gene therapy Genes, Tumor Suppressor Genetic Therapy - methods Genetic Vectors Hepatocytes Humans Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism Interleukin 24 Interleukins - genetics Interleukins - metabolism Laboratory animals Liver cancer Liver Neoplasms - pathology Lung cancer Lung Neoplasms - pathology Male Mice Mice, Inbred BALB C Mice, Nude mitotic arrest MPHOSPH1 Oncolysis oncolytic adenoviral vector Oncolytic Viruses - genetics Original Ovarian cancer Ovarian Neoplasms - pathology Plasmids post‐mitotic apoptosis Proteins Reporter gene Repressor Proteins RNA, Small Interfering - genetics Senescence Survivin Tumor cell lines Tumor suppressor genes Tumors Xenograft Model Antitumor Assays
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