Pharmacotherapeutic targets in Alzheimer's disease

• Current pharmacotherapies for the treatment of AD • AD pharmacotherapies targeting τ ‐ Modulators of – kinases or phosphatases ‐ τ aggregation inhibitors (TAIs) • AD pharmacotherapies targeting Aβ ‐ Inhibitors and/or modulators of the secretases ‐ Aβ aggregation inhibitors ‐ Passive or act...

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of cellular and molecular medicine 2009-01, Vol.13 (1), p.61-86
Hauptverfasser:	Biran, Yif'at, Masters, Colin L., Barnham, Kevin J., Bush, Ashley I., Adlard, Paul A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Amino Acid Sequence Amyloid beta-Peptides - metabolism Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism amyloid‐β Animals Antibodies - therapeutic use Antioxidants - therapeutic use Brain Chelating agents Cognitive ability Dementia Disease Drug development Drug dosages Drug therapy Enzyme Inhibitors - therapeutic use Humans Immunization Immunological memory Kinases Metal ions metals Metals - chemistry Molecular Sequence Data Neurodegenerative diseases Neuromodulation Older people Peptides Phosphatase Phosphorylation Proteins Reviews tau Proteins - antagonists & inhibitors tau Proteins - metabolism therapeutics Vaccination β-Amyloid
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