Interplay between Ca2+ cycling and mitochondrial permeability transition pores promotes reperfusion‐induced injury of cardiac myocytes

Uncontrolled release of Ca2+ from the sarcoplasmic reticulum (SR) contributes to the reperfusion‐induced cardiomyocyte injury, e.g. hypercontracture and necrosis. To find out the underlying cellular mechanisms of this phenomenon, we investigated whether the opening of mitochondrial permeability tran...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2011-11, Vol.15 (11), p.2478-2485
Hauptverfasser:	Abdallah, Yaser, Kasseckert, Sascha A., Iraqi, Wisam, Said, Maher, Shahzad, Tayyab, Erdogan, Ali, Neuhof, Christiane, Gündüz, Dürsün, Schlüter, Klaus‐Dieter, Tillmanns, Harald, Piper, H. Michael, Reusch, H. Peter, Ladilov, Yury
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Acetylcysteine - pharmacology Adenosine Triphosphate - metabolism Animals Calcein Calcium (intracellular) Calcium (mitochondrial) Calcium (reticular) Calcium - metabolism Calcium influx Calcium permeability Calcium sequestration Calcium signalling Cardiac muscle cardiac myocytes Cardiomyocytes Cyclosporine - pharmacology Cyclosporins Fluoresceins - analysis Fura-2 Heart Investigations Ischemia Laboratory animals Magnesium Male Membrane permeability Membrane Potential, Mitochondrial - drug effects Mitochondria Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial permeability transition pore MPTP Myocardial Reperfusion Injury - metabolism Myocytes Myocytes, Cardiac - physiology Necrosis Original Permeability Photonics Pores Rats Rats, Wistar Reactive oxygen species Reactive Oxygen Species - metabolism Reperfusion reperfusion injury Ruthenium Compounds - pharmacology Ryanodine - pharmacology Sarcoplasmic reticulum Thapsigargin - pharmacology Tiopronin - pharmacology
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