Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation
We report that several nanomaterials induced enhanced mineralization (increased numbers and larger areas of mineral nests) in MC3T3‐E1 bone cells, with the highest response being induced by silver nanoparticles (AgNPs). We demonstrate that AgNPs altered microRNA expression resulting in specific gene...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2011-11, Vol.15 (11), p.2297-2306 |
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| creator | Mahmood, Meena Li, Zhiguang Casciano, Daniel Khodakovskaya, Mariya V. Chen, Tao Karmakar, Alokita Dervishi, Enkeleda Xu, Yang Mustafa, Thikra Watanabe, Fumiya Fejleh, Ashley Whitlow, Morgan Al‐Adami, Mustafa Ghosh, Anindya Biris, Alexandru S. |
| description | We report that several nanomaterials induced enhanced mineralization (increased numbers and larger areas of mineral nests) in MC3T3‐E1 bone cells, with the highest response being induced by silver nanoparticles (AgNPs). We demonstrate that AgNPs altered microRNA expression resulting in specific gene expression associated with bone formation. We suggest that the identified essential transcriptional factors and bone morphogenetic proteins play an important role in activation of the process of mineralization in bone cells exposed to AgNPs. |
| doi_str_mv | 10.1111/j.1582-4934.2010.01234.x |
| format | Article |
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We demonstrate that AgNPs altered microRNA expression resulting in specific gene expression associated with bone formation. We suggest that the identified essential transcriptional factors and bone morphogenetic proteins play an important role in activation of the process of mineralization in bone cells exposed to AgNPs.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/j.1582-4934.2010.01234.x</identifier><identifier>PMID: 21143388</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>3T3 Cells ; Alkaline Phosphatase - metabolism ; Animals ; Bone and Bones - cytology ; bone cells ; Bone growth ; Bone morphogenetic proteins ; Bone Morphogenetic Proteins - metabolism ; Calcification ; Calcification, Physiologic - drug effects ; Calcification, Physiologic - genetics ; Carbon ; Cell activation ; Cell Line ; Cells ; Electron microscopes ; Gene Expression ; Genetic engineering ; Metal Nanoparticles ; Mice ; MicroRNAs ; MicroRNAs - metabolism ; Mineralization ; miRNA ; miRNA regulation ; Nanomaterials ; Nanoparticles ; Nanostructures ; Nanotechnology ; Original ; Osteoblasts - metabolism ; Osteogenesis ; Proteins ; Scanning electron microscopy ; Silver ; Spectrum analysis ; Transcription activation ; Transcription factors</subject><ispartof>Journal of cellular and molecular medicine, 2011-11, Vol.15 (11), p.2297-2306</ispartof><rights>2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd</rights><rights>2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.</rights><rights>2011. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5024-5b7548acadbc75d779e4ddad95ef51e48ef1bd74df1a58960c8ca7561c7b4b5d3</citedby><cites>FETCH-LOGICAL-c5024-5b7548acadbc75d779e4ddad95ef51e48ef1bd74df1a58960c8ca7561c7b4b5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822941/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822941/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1582-4934.2010.01234.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21143388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahmood, Meena</creatorcontrib><creatorcontrib>Li, Zhiguang</creatorcontrib><creatorcontrib>Casciano, Daniel</creatorcontrib><creatorcontrib>Khodakovskaya, Mariya V.</creatorcontrib><creatorcontrib>Chen, Tao</creatorcontrib><creatorcontrib>Karmakar, Alokita</creatorcontrib><creatorcontrib>Dervishi, Enkeleda</creatorcontrib><creatorcontrib>Xu, Yang</creatorcontrib><creatorcontrib>Mustafa, Thikra</creatorcontrib><creatorcontrib>Watanabe, Fumiya</creatorcontrib><creatorcontrib>Fejleh, Ashley</creatorcontrib><creatorcontrib>Whitlow, Morgan</creatorcontrib><creatorcontrib>Al‐Adami, Mustafa</creatorcontrib><creatorcontrib>Ghosh, Anindya</creatorcontrib><creatorcontrib>Biris, Alexandru S.</creatorcontrib><title>Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>We report that several nanomaterials induced enhanced mineralization (increased numbers and larger areas of mineral nests) in MC3T3‐E1 bone cells, with the highest response being induced by silver nanoparticles (AgNPs). We demonstrate that AgNPs altered microRNA expression resulting in specific gene expression associated with bone formation. We suggest that the identified essential transcriptional factors and bone morphogenetic proteins play an important role in activation of the process of mineralization in bone cells exposed to AgNPs.</description><subject>3T3 Cells</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Bone and Bones - cytology</subject><subject>bone cells</subject><subject>Bone growth</subject><subject>Bone morphogenetic proteins</subject><subject>Bone Morphogenetic Proteins - metabolism</subject><subject>Calcification</subject><subject>Calcification, Physiologic - drug effects</subject><subject>Calcification, Physiologic - genetics</subject><subject>Carbon</subject><subject>Cell activation</subject><subject>Cell Line</subject><subject>Cells</subject><subject>Electron microscopes</subject><subject>Gene Expression</subject><subject>Genetic engineering</subject><subject>Metal Nanoparticles</subject><subject>Mice</subject><subject>MicroRNAs</subject><subject>MicroRNAs - metabolism</subject><subject>Mineralization</subject><subject>miRNA</subject><subject>miRNA regulation</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanostructures</subject><subject>Nanotechnology</subject><subject>Original</subject><subject>Osteoblasts - metabolism</subject><subject>Osteogenesis</subject><subject>Proteins</subject><subject>Scanning electron microscopy</subject><subject>Silver</subject><subject>Spectrum analysis</subject><subject>Transcription activation</subject><subject>Transcription 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materials increase mineralization in bone cells and affect gene expression through miRNA regulation</title><author>Mahmood, Meena ; Li, Zhiguang ; Casciano, Daniel ; Khodakovskaya, Mariya V. ; Chen, Tao ; Karmakar, Alokita ; Dervishi, Enkeleda ; Xu, Yang ; Mustafa, Thikra ; Watanabe, Fumiya ; Fejleh, Ashley ; Whitlow, Morgan ; Al‐Adami, Mustafa ; Ghosh, Anindya ; Biris, Alexandru S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5024-5b7548acadbc75d779e4ddad95ef51e48ef1bd74df1a58960c8ca7561c7b4b5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>3T3 Cells</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Bone and Bones - cytology</topic><topic>bone cells</topic><topic>Bone growth</topic><topic>Bone morphogenetic proteins</topic><topic>Bone Morphogenetic Proteins - metabolism</topic><topic>Calcification</topic><topic>Calcification, 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mineralization in bone cells and affect gene expression through miRNA regulation</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2011-11</date><risdate>2011</risdate><volume>15</volume><issue>11</issue><spage>2297</spage><epage>2306</epage><pages>2297-2306</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>We report that several nanomaterials induced enhanced mineralization (increased numbers and larger areas of mineral nests) in MC3T3‐E1 bone cells, with the highest response being induced by silver nanoparticles (AgNPs). We demonstrate that AgNPs altered microRNA expression resulting in specific gene expression associated with bone formation. We suggest that the identified essential transcriptional factors and bone morphogenetic proteins play an important role in activation of the process of mineralization in bone cells exposed to AgNPs.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21143388</pmid><doi>10.1111/j.1582-4934.2010.01234.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3T3 Cells Alkaline Phosphatase - metabolism Animals Bone and Bones - cytology bone cells Bone growth Bone morphogenetic proteins Bone Morphogenetic Proteins - metabolism Calcification Calcification, Physiologic - drug effects Calcification, Physiologic - genetics Carbon Cell activation Cell Line Cells Electron microscopes Gene Expression Genetic engineering Metal Nanoparticles Mice MicroRNAs MicroRNAs - metabolism Mineralization miRNA miRNA regulation Nanomaterials Nanoparticles Nanostructures Nanotechnology Original Osteoblasts - metabolism Osteogenesis Proteins Scanning electron microscopy Silver Spectrum analysis Transcription activation Transcription factors |
| title | Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation |
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