Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma

A role of heat shock protein 27 (HSP27) as a potential biomarker has been reported in various tumour entities, but comprehensive studies in pancreatic cancer are lacking. Applying tissue microarray (TMA) analysis, we correlated HSP27 protein expression status with clinicopathologic parameters in pan...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2012-08, Vol.16 (8), p.1776-1791
Hauptverfasser:	Schäfer, Claus, Seeliger, Hendrik, Bader, Dominik C., Assmann, Gerald, Buchner, Denise, Guo, Yang, Ziesch, Andreas, Palagyi, Andreas, Ochs, Stephanie, Laubender, Rüdiger P., Jung, Andreas, De Toni, Enrico N., Kirchner, Thomas, Göke, Burkhard, Bruns, Christiane, Gallmeier, Eike
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged Aged, 80 and over Antigens biomarker Biomarkers Biomarkers, Tumor - metabolism Biopsy Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell culture Cell Line, Tumor Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Drug Screening Assays, Antitumor Female Gemcitabine Heat shock proteins Heat-Shock Response - drug effects HSP27 HSP27 Heat-Shock Proteins - metabolism Hsp27 protein Humans Hyperthermia Immunohistochemistry Kaplan-Meier Estimate Male Medical prognosis Middle Aged Monoclonal antibodies Multivariate Analysis Original p53 Protein Pancreas - metabolism Pancreas - pathology Pancreatectomy Pancreatic cancer Pancreatitis Patients Phosphorylation Prognosis Protein expression Protein interaction Radiosensitivity RNA-mediated interference Surgery Tissue Array Analysis TMA Tumor cell lines Tumors
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