Innate Immune Tolerance and the Role of Kupffer Cells in Differential Responses to Interferon Therapy Among Patients With HCV Genotype 1 Infection

Background & Aims In patients with hepatitis C virus (HCV) infection, interferon alfa (IFN-α) alters expression of IFN-stimulated genes (ISGs), but little is understood about factors that determine outcomes of therapy. We used a systems biology approach to evaluate the acute response of patients...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2013-02, Vol.144 (2), p.402-413.e12
Hauptverfasser:	Lau, Daryl T.–Y, Negash, Amina, Chen, Jie, Crochet, Nanette, Sinha, Mala, Zhang, Yuhong, Guedj, Jeremie, Holder, Sharon, Saito, Takeshi, Lemon, Stanley M, Luxon, Bruce A, Perelson, Alan S, Gale, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biopsy Cells, Cultured Drug Female Follow-Up Studies Gastroenterology and Hepatology Gene Expression Regulation Genotype Hepacivirus - genetics Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - genetics Hepatitis C, Chronic - immunology Hepatocytes - immunology Hepatocytes - metabolism Hepatocytes - virology Humans Immune Tolerance - drug effects Immunity, Innate - drug effects Immunity, Innate - immunology Interferon alpha-2 Interferon Regulatory Factors - biosynthesis Interferon Regulatory Factors - genetics Interferon-alpha - therapeutic use Kupffer Cells - drug effects Kupffer Cells - immunology Liver - immunology Liver - pathology Liver - virology Male Microarray Analysis Middle Aged Models, Theoretical PBMC Recombinant Proteins - therapeutic use RNA, Viral - genetics Therapeutic Efficacy Viral Load Young Adult
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