Arteriolar niches maintain haematopoietic stem cell quiescence

Cell cycle quiescence is a critical feature contributing to haematopoietic stem cell (HSC) maintenance. Although various candidate stromal cells have been identified as potential HSC niches, the spatial localization of quiescent HSCs in the bone marrow remains unclear. Here, using a novel approach t...

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Veröffentlicht in:	Nature (London) 2013-10, Vol.502 (7473), p.637-643
Hauptverfasser:	Kunisaki, Yuya, Bruns, Ingmar, Scheiermann, Christoph, Ahmed, Jalal, Pinho, Sandra, Zhang, Dachuan, Mizoguchi, Toshihide, Wei, Qiaozhi, Lucas, Daniel, Ito, Keisuke, Mar, Jessica C., Bergman, Aviv, Frenette, Paul S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/532/2139 692/308/2171 Animals Arteries Arterioles - cytology Bone marrow Bone Marrow - blood supply Cell cycle Cell Division Cell Separation Female Flow Cytometry Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humanities and Social Sciences Male Mesenchymal Stromal Cells - cytology Mice Mice, Inbred C57BL multidisciplinary Nestin - metabolism Physiological aspects Science Stem Cell Niche Stem cells Studies Transplants & implants
Online-Zugang:	Volltext
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