Generation of an ICF syndrome model by efficient genome editing of human induced pluripotent stem cells using the CRISPR system

Genome manipulation of human induced pluripotent stem (iPS) cells is essential to achieve their full potential as tools for regenerative medicine. To date, however, gene targeting in human pluripotent stem cells (hPSCs) has proven to be extremely difficult. Recently, an efficient genome manipulation...

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Veröffentlicht in:	International journal of molecular sciences 2013-09, Vol.14 (10), p.19774-19781
Hauptverfasser:	Horii, Takuro, Tamura, Daiki, Morita, Sumiyo, Kimura, Mika, Hatada, Izuho
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Base Sequence Cell Line Cloning Clustered Regularly Interspaced Short Palindromic Repeats - genetics Communication CRISPR DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methyltransferase 3B Efficiency Gene Targeting - methods Genes Genetic engineering Genetic Engineering - methods Genome - genetics Genomes Humans Hypertelorism - genetics Immune system Induced Pluripotent Stem Cells - metabolism Intellectual Disability - genetics Kyphosis - genetics Megalencephaly - genetics Molecular Sequence Data Mutation Plasmids Proteins Regenerative medicine RNA Editing - genetics Stem cells Tongue - abnormalities
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