Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway

Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown efficacy in a phase 2 clinical trial, development of resistance to TRAIL by tumor cells is a major roadblock. We investigated whether azadirone, a limonoidal tetranortriterpene, can sensitize human tumor cells to TRAI...

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Veröffentlicht in:	The Journal of biological chemistry 2013-11, Vol.288 (45), p.32343-32356
Hauptverfasser:	Gupta, Subash C, Francis, Sajin K, Nair, Mangalam S, Mo, Yin-Yuan, Aggarwal, Bharat B
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Regulatory Proteins - biosynthesis Cell Line, Tumor Cell Survival Dose-Response Relationship, Drug Down-Regulation - drug effects Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation, Neoplastic - drug effects Humans Limonins - pharmacology MAP Kinase Signaling System - drug effects Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Reactive Oxygen Species - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Response Elements Signal Transduction TNF-Related Apoptosis-Inducing Ligand - pharmacology Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Up-Regulation - drug effects
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