Mesenchyme-specific Knockout of ESET Histone Methyltransferase Causes Ectopic Hypertrophy and Terminal Differentiation of Articular Chondrocytes

The exact molecular mechanisms governing articular chondrocytes remain unknown in skeletal biology. In this study, we have found that ESET (an ERG-associated protein with a SET domain, also called SETDB1) histone methyltransferase is expressed in articular cartilage. To test whether ESET regulates a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2013-11, Vol.288 (45), p.32119-32125
Hauptverfasser:	Lawson, Kevin A., Teteak, Colin J., Zou, Junhui, Hacquebord, Jacques, Ghatan, Andrew, Zielinska-Kwiatkowska, Anna, Fernandes, Russell J., Chansky, Howard A., Yang, Liu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Animals Arthritis Articular cartilage Cartilage biology Cartilage, Articular - enzymology Cartilage, Articular - pathology Cell Biology Cell Differentiation Chondrocytes Chondrocytes - enzymology Chondrocytes - pathology Collagen Type II - genetics Collagen Type II - metabolism Differentiation Epigenetics Gene Knockout Histone methylation Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Hypertrophy - enzymology Hypertrophy - genetics Hypertrophy - pathology Knee Joint - enzymology Knee Joint - pathology Matrix Metalloproteinase 13 - genetics Matrix Metalloproteinase 13 - metabolism Mice Mice, Knockout Organ Specificity - genetics Osteoarthritis, Knee - enzymology Osteoarthritis, Knee - genetics Osteoarthritis, Knee - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!